何书英， 中国药科大学化学制药专业学士、生物制药专业硕士、药理学专业博士。现任中国药科大学生命科学与技术学院专业课实验中心主任、教授、硕士生导师。曾主持低分子量肝素钠原料、注射液及冻干针剂项目，获国家药品监督管理局批准的生产证书及批文。2004年至今任教于中国药科大学生命科学与技术学院，从事教学及科研工作。2012年3月至2013年3月密歇根大学访问学者。主要讲授《生物制药工艺学》及《生化药物分析》课程。研究方向为生化药理学，主持及承担的课题有：江苏省自然科学基金《多靶点肿瘤血管生成抑制剂的设计合成及生物活性研究》，江苏省分子医学生物技术重点实验室开放研究基金项目《肝素寡糖抗平滑肌细胞增殖机制研究》,江苏省“六大人才高峰”资助项目《基于rPmHAS 的双酶反应器循环合成单一分子量透明质酸》, 重大新药创制国家重大专项《糖类药物制备及质量控制关键技术》，中央高校基本科研业务费专项基金《肝素十二糖抗血管平滑肌细胞增殖的活性及机制研究》。近年来在国内外学术期刊上发表论文30多篇，其中SCI论文19篇，授权专利2项，主编、副主编教材三部。入选2008年江苏省“六大人才高峰”培养人选，承担的课程《生物制药工艺学》2019年获国家精品在线开放课程及2010年国家优秀教学团队。

讲授课程

《生物制药工艺学》及《生化药物分析》

研究方向

生物大分子的结构与功能研究；

微生物和生化药物相关的基础研究；

药物相关基因的表达与调控；

发表论文

1.       Fahad Akhtar, Xinyu Wan, Gang Wu, Samuel Kesse, Shaoda Wang and Shuying He,* Low-Molecular-Weight Heparins: Reduced Size Particulate Systems for Improved Therapeutic Outcomes, molecules, 2018, 23:1757-1768.

2.       Jie-ru Liu, Hui-fang Wang, Dan-feng Yu, Xiao-yu Chen, Shu-ying He*. Modulation of binding to vascular endothelial growth factor and receptor by heparin derived oligosaccharide. Carbohydrate Polymers, 2017, 174:558-564.

3.       LIU Jie-Ru, WU Jie, YU Xin-Chao, QIAN Xuan, XIONG Rui, WANG Hui-Fang, YU Dan-Feng, LIU Fei-Fei, HE Shu-Ying*. Heparin-derived oligosaccharide inhibits vascular intimal hyperplasia in balloon-injured carotid artery .Chinese Journal of Natural Medicines, 2017, 15(6): 0442-0450.

4.   RUI XIONG, JING SUN, KUN LIU, YUNGEN XU and SHUYING HE*. Effect of CPU-XT-008, a combretastatin A-4 analogue, on the proliferation, apoptosis and expression of vascular endothelial growth factor and basic fibroblast growth factor in human umbilical vein endothelial cells. Oncology Letters, 2016, 11: 491-499.

5.       Danfeng Yu, Xue Rui, Shuying He*.Effect of Heparin-Derived Oligosaccharide on bFGFR1 and bFGFR2 in Vascular Smooth Muscle Cells. Vascular and Endovascular Surgery. 2014, 48(4): 289-296.

6.       Yan Tang, Zhewei Tu, Jing Sun, Xiong Zhu#, Kun Liu, Shuying He, Yungen Xu*.Design, Synthesis and Biological Evaluation of Novel Aminosaccharide Derivatives of Combretastatin A-4.Lett Drug Des Discov. 2013,10: (10), 935-941

7.       Li Li, Xue Rui, Tongfei Liu, Guanglin Xu, Shuying He*. Effect of Heparin-Derived Oligosaccharide on Vascular Smooth Muscle Cell Proliferation and the Signal Transduction Mechanisms Involved. Cardiovascular Drugs and Therapy.2012,26(6): 479-488.

8.       Li Li, Wei Li, Zhong Ren, ShuYing He*, GuangLin Xu, and LiNa Yang. Effect of Heparin-Derived Oligosaccharide on Vascular Smooth Muscle Cell Proliferation. Vascular and Endovascular Surgery.2012, 46(5): 393-400.

9.       Li Chen, Wen Qiu , Jia Tang , Zhi Feng Wang , Shu Ying He* . Synthesis and bioactivity of novel nitric oxide-releasing ursolic acid derivatives. Chinese Chemical Letters, 2011, 22:413-416.

10.    Zhou CH, Xiang M, He SY, Qian ZY. Crocetin inhibits cell cycle G1/S transition through suppressing cyclin D1 and elevating p27kip1  in vascular smooth muscle cells. Phytother Res. 2010 ,24(7): 975-81.

11.    Guanglin Xu, Fei Liu, Guizhen Ao, Shuying He, Min Ju,Yue Zhao, Ting Xue. Anti-inflammatory effects and gastrointestinal safety of NNU-hdpa, a novel dual COX/5-LOX inhibitor. European journal of pharmacology,2009,611:100-106.

12.    Cheng-Hua Zhou, Zhi-Yu Qian, Min Xiang, Shu-Ying He.Involvement of Ca2+ in the inhibition by crocetin of angiotensin II-induced ERK1/2 activation in vascular smooth muscle cells .European Journal of Pharmacology, 554 (2007) 85–91.

13.    Guanglin Xu, Zhunan Gong, Weiping Yu, Lei Gao, Shuying He, Zhiyu Qian. Increased Expression Ratio of bcl-2/bax Is Asssociated with Crocin-mediated Apoptosis in Bovine Aortic Endothelial Cells. Basic & Clinical Pharmacology & Toxicology, 2007,100 (1):31-35.

14.    Shu-Ying He, Zhi-Yu Qian, Na Wen, Fu-Tian Tang, Guang-Lin Xu, Cheng-Hua Zhou .Influence of Crocetin on experimental atherosclerosis in hyperlipidamic-diet quails. European Journal of Pharmacology, 2007, 554:191-195.

15.    Tang FT, Qian ZY, Liu PQ, Zheng SG, He SY, Bao LP, Huang HQ. Crocetin improves endothelium-dependent relaxation of thoracic aorta in hypercholesterolemic rabbit by increasing eNOS activity. Biochem Pharmacol. 2006 Aug 28;72(5):558-65.

16.    Guanglin Xu, Qiaoli Liang, Zhunan. Gong, Weiping Yu, Shuying He, Liang Xi. Antitumor activities of the four sesquiterpene lactones from Elephantopus Scaber L. Experimental Oncology, 2006,28(2):106-109.

17.    Shu-Ying He, Zhi-Yu QianT, Fu-Tian Tang, Na Wen, Guang-Lin Xu, Liang Sheng. Effect of Crocin on Experimental Atherosclerosis in Quails and Its Mechanisms. Life Sciences, 2005,77 (8):907-921.

18.    LI Li, GAO Ting, HE Shu-ying*, XU Guang-lin, YANG Li-na. Effect of heparin-derived oligosaccharide on vascular smooth muscle cell proliferation through inhibition of PKC-α expression.药学学报,2012,47 (8): 993-1000.

19.    HE Shu-Ying,QIAN Zhi-Yu, TANG Fu-Tian. Effect of Crocin on Calcium Concentration in Cultured Bovine Aortic Smooth Muscle Cells.药学学报,2004,39(10):778-781.

20.    张玲玲,季璇馨,刘洁茹,黄青林,何书英*.肝素寡糖对脂多糖诱导人脐静脉内皮细胞炎症的影响及分子机制研究.中国药科大学学报,2016,47(5):619-624.

21.  何书英,王慧芳,俞丹凤,袁静.肝素寡糖抑制血小板衍生生长因子诱导平滑肌细胞增殖机制的研究. 药学学报,2015, 50 (8): 993-999.

22.    王文荟,何书英*.肝素黄杆菌的明胶固定化.药物生物技术,2013,20(1):29-33.

23.    何书英,熊蕊,刘坤,徐云根. Combretastatin A- 4 氨基糖类衍生物 CPU-XT-008抑制血管内皮细胞增殖的分子机制.中国药科大学学报,2015,46(5):594-599.

24.  孙海娇,何书英*.肝素寡糖抑制血管内皮细胞生长的机制研究.药物生物技术,2014,21(6):530-533.

25.    何书英*,孙菁,刘坤,徐云根.考布他汀A-4衍生物CPU-XT-006对人脐静脉内皮细胞增殖、凋亡及VEGF、bFGF表达的影响中国药科大学学报. 2013, 44(5):451-454.

26.    李巍,陈丽萍,李莉,绪广林,何书英*.肝素十二糖对血管平滑肌细胞增殖作用的研究,中国临床药理学与治疗学,2011,16(8):862- 867.

27.    何书英, 高婷,绪广林.梯度电泳制备肝素寡糖.药物生物技术,2011,18(5):426-429.

28.    陈丽萍,何书英*,郑珩,戴雨璐.番茄红素对牛胸主动脉平滑肌细胞增殖的作用及作用机制, 中国天然药物杂志,2010, 8(3):0218-0222.

29.    牛佳,何书英*,李巍,王丽荣.肝素寡糖的制备及其对平滑肌细胞抗增生作用的初步研究.药物生物技术, 2009,16(1):46-49.

30.    刘亚梅,何书英*,吴梧桐.酶法制备低分子量肝素及其活性研究.药物生物技术,2007,14(4): 277-280.

31.    何书英,李华,杨宁.亲和色谱分离纯化低分子肝素.中国生化药物杂志,2006,27 (3):170-171.

32.    何书英,钱之玉.西红花苷对低密度脂蛋白所致鹌鹑内皮细胞损伤的保护作用.华西药学杂志,2006,21(1): 028-031.

33.    何书英,钱之玉.西红花苷对氧化性低密度脂蛋白所致内皮细胞损伤的保护作用.中国新药杂志,2005,14(2): 169-173.

34.    何书英,钱之玉,绪广林.西红花苷对平滑肌细胞增殖的影响及机制探讨.中国药科大学学报, 2004, 35(1): 65-68.