袁浩亮，男，博士，中国药科大学多靶标天然药物全国重点实验室研究员，博士生导师。主持国家自然科学基金面上项目3项、青年项目1项、重庆市自然科学基金面上项目1项，中央高校基本科研业务费项目2项，另参与多项国家和省部级科研项目。以第一作者/通讯作者在药物化学专业领域J. Med. Chem.，Eur. J. Med. Chem.，J. Chem. Inf. Model.等期刊发表SCI论文20余篇，申请国内/外专利多项，参与多项1.1类新药成果转化。

研究方向：计算机辅助药物分子发现及新药研究

联系方式：yhl@cpu.edu.cn

通讯地址：江苏省南京市江宁区龙眠大道639号中国药科大学，邮编：211198

代表性论文：

(1)  Panpan Chen#, Cai Chen#, Yizheng Zheng, Fangjun Chen, Zhaojun Liu, Shenhong Ren, Hangyu Song, Tongdan Liu, Zhipeng Lu, Hongbin Sun*, Yi Kong*, and Haoliang Yuan*, Discovery of 2, 3-dihydro-[1,4]dioxino[2,3-g]benzofuran Derivatives as Protease Activated Receptor 4 (PAR4) Antagonists with Potent Antiplatelet Aggregation Activity And Low Bleeding Tendency, J. Med. Chem. 2024, doi: 10.1021/acs.jmedchem.3c02099.

(2)  Liu Liu#, Honghan Zhang#, Jie Hou#, Yuying Zhang#, Luosen Wang, Shijun Wang, Zhiying Yao, Tao Xie, Xiaoan Wen, Qinglong Xu, Liang Dai, Zhiqi Feng, Pu Zhang, Yaojun Wu, Hongbin Sun*, Jun Liu*, Haoliang Yuan*. Discovery of Novel PD-L1 Small-Molecular Inhibitors with Potent In Vivo Anti-tumor Immune Activity, J. Med. Chem. 2024, 67:4977-4997.

(3)  Hengzhi Sun#, Jinzheng Wang#, Shengjie Liu#, Xinyu Zhou#, Liang Dai, Caiping Chen, Qinglong Xu, Xiaoan Wen, Keguang Cheng, Hongbin Sun*, Haoliang Yuan*, Discovery of Novel Small Molecule Inhibitors Disrupting the PCSK9-LDLR Interaction. J. Chem. Inf. Model. 2021, 61, 5269-5279. 

(4)  Liu Liu#, Zhiying Yao#, Shijun Wang#, Tao Xie, Guoqing Wu, Honghan Zhang, Pu Zhang, Yaojun Wu, Haoliang Yuan*, Hongbin Sun*. Syntheses, Biological Evaluations, and Mechanistic Studies of Benzo[C][1,2,5]Oxadiazole Derivatives as Potent Pd-L1 Inhibitors with in Vivo Antitumor Activity. J. Med. Chem. 2021, 64, 8391-8409. 

(5)  Shengjie Liu, Xinyu Zhou, Minglei Li, Wenfeng Zhao, Shuxi Zhou, Ke-guang Cheng, Qing-Long Xu, Caiping Chen, Xiaoan Wen, Hongbin Sun*, Haoliang Yuan*. Discovery of Ubiquitin Specific Protease 7 (USP7) Inhibitors with A Novel Scaffold Structure by Virtual Screening, Molecular Dynamics Simulation and Biological Evaluation. J. Chem. Inf. Model. 2020, 60, (6): 3255–3264.