温小安，中国药科大学研究员。1998年和2007年于中国药科大学分别获化学制药学士学位和药物化学博士学位。2010-2012年受国家留学基金委和法中科学及应用基金会资助，于法国里尔第二大学从事博士后研究。获2009年全国优秀博士学位论文提名奖、2009年第十二届中国药学会施维雅青年药物化学奖及2018年江苏省科学技术奖三等奖（排名第3）。主持国家自然科学基金、江苏省自然科学基金等基金资助科研项目10余项。在Journal of Medicinal Chemistry、European Journal of Medicinal Chemistry、British Journal of Pharmacology等期刊发表SCI论文60余篇，获授权专利10余件。

研究方向

代谢与免疫调控新药发现

获奖与荣誉

2018年江苏省科学技术奖三等奖（排名第3）

2009年全国优秀博士学位论文提名奖

2009年第十二届中国药学会施维雅青年药物化学奖

“Bioorganic & Medicinal Chemistry Letters” Most Cited Paper 2006-2009 Award

代表性论文

(1) Yanhong Pan, Yanping You, Li Sun, Qibang Sui, Liu Liu, Haoliang Yuan, Caiping Chen, Jun Liu, Xiaoan Wen*, Liang Dai*, Hongbin Sun*, The STING antagonist H-151 ameliorates psoriasis via suppression of STING/NF-κB-mediated inflammation, British Journal of Pharmacology 2021, 178, 4907. 

(2) Minglei Li, Shengjie Liu, Hui Chen, Xinyu Zhou, Jin Zhou, Shuxi Zhou, Haoliang Yuan, Qing-Long Xu, Jun Liu, Keguang Cheng, Hongbin Sun, Yue Wang*, Caiping Chen*, Xiaoan Wen*, N-benzylpiperidinol derivatives as novel USP7 inhibitors: structure–activity relationships and X-ray crystallographic studies, European Journal of Medicinal Chemistry 2020, 199, 112279.

(3) Geng Sun, Yanping You, Haobin Li, Yalong Cheng, Ming Qian, Xinyu Zhou, Haoliang Yuan, Qing-Long Xu, Liang Dai, Pengfei Wang, Keguang Cheng, Xiaoan Wen*, Caiping Chen*, Discovery of AdipoRon analogues as novel AMPK activators without inhibiting mitochondrial complex I, European Journal of Medicinal Chemistry 2020, 200, 112466.

(4) Jin Zhou, Jinzheng Wang, Chao Chen, Haoliang Yuan, Xiaoan Wen*, Hongbin Sun*, USP7: target validation and drug discovery for cancer therapy, Medicinal Chemistry 2018, 14 (1), 3-18.

(5) Le Zhen, Liang Dai (co-first author), Xiaoan Wen(co-first author), Lan Yao, Xiaoliang Jin, Xiao-Wen Yang, Wenfeng Zhao, Sheng-Qi Yu, Haoliang Yuan, Guangji Wang*, Hongbin Sun*, Discovery of Novel Nucleotide Prodrugs with Improved Potency Against HCV Variants Carrying NS5B S282T Mutation, Journal of Medicinal Chemistry 2017, 60 (14), 6077–6088.

(6) Zuojuan Xiang, Jun Liu, Hongbin Sun*, Xiaoan Wen*, Discovery of Novel Potent Muscarinic M3 Receptor Antagonists with Proper Plasma Stability by Structural Recombination of Marketed M3 Antagonists, ChemMedChem 2017, 12 (15), 1173–1182.

(7) Dongyin Chen, Xin Huang, Hongwen Zhou, Hanqiong Luo, Pengfei Wang, Yongzhi Chang, Xinyi He, Suiying Ni, Qingqing Shen, Guoshen Cao, Hongbin Sun, Xiaoan Wen*, Jun Liu*, Discovery of pentacyclic triterpene 3β-ester derivatives as a new class of cholesterol ester transfer protein inhibitors, European Journal of Medicinal Chemistry 2017, 139, 201–213.

(8) Yongzhi Chang, Shuxi Zhou, Enqin Li, Wenfeng Zhao, Yanpeng Ji, Xiaoan Wen*, Hongbin Sun*, Haoliang Yuan*, Fragment-based discovery of novel pentacyclic triterpenoid derivatives as cholesteryl ester transfer protein inhibitors, European Journal of Medicinal Chemistry 2017, 126, 143–153.

(9) Xiaowei Sun, Xiaoan Wen (co-first author), Yan-yan Chen, Chen Shi, Chengzhe Gao, Yong Wu, Li-jun Wang, Xiu-hong Yang*, Hongbin Sun*. Discovery of highly potent renin inhibitors potentially interacting with the S3′ subsite of renin. European Journal of Medicinal Chemistry 2015, 103, 269–288.

(10) Xiaoan Wen, Hongbin Sun*, Jun Liu, Keguang Cheng, Pu Zhang, Liying Zhang, Jia Hao, Luyong Zhang, Peizhou Ni, Spyros E. Zographos, Demetres D. Leonidas, Kyra-Melinda Alexacou, Thanasis Gimisis, Joseph M. Hayes, Nikos G. Oikonomakos*, Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: Synthesis, structure-activity relationships, and X-ray crystallographic studies, Journal of Medicinal Chemistry 2008, 51 (12), 3540–3554.

联系方式

电子信箱: wxagj@cpu.edu.cn

办公电话: 025-83271050

通信地址: 南京市童家巷24号，中国药科大学新药研究中心，邮编: 210009