2000年本科毕业于中国药科大学,2004年获得华东师范大学生物化学与分子生物学专业硕士学位,2013年获得中国药科大学药理学博士学位。2008年至2009年至美国弗吉尼亚联邦大学进行为期一年的交流访问。2004年硕士毕业后在中国药科大学新药筛选中心工作至今。
主要从事分子药理学和药物毒理学研究,主要研究方向为:药源性肝肠损伤及肝脏、肠道疾病的分子机制研究;药物对肝脏毒性作用机制和物质基础研究;炎症性肠病的分子机制研究及内源性代谢物对肠道免疫的影响。
(1) 国家自然科学基金面上项目,82074115,肠神经元芳香烃受体/乙酰胆碱酯酶信号通路介导的青黛肠道不良反应研究,2021-2024,主持。
(2) 国家自然科学基金面上项目,81873084,基于LncRNA介导的肝窦内皮细胞线粒体功能障碍探讨吡咯里西啶生物碱的肝毒性机制,2019-2022,主持。
(3)国家自然科学基金面上项目,81573690,基于Nrf2信号通路调控枯否细胞极性的雷公藤甲素肝毒性作用机制研究,2016-2019,主持。
(4) 1-磷酸鞘氨醇/1-磷酸鞘氨醇激酶通路介导的雷公藤毒效相关性研究 (No. 81102887),国家自然科学基金,时间:2012-2014,主持。
(5) 二萜类中药单体TR1作用于mRNA结合蛋白HuR的抗炎机制研究(No.BK BK2010433),江苏省自然基金面上项目,时间:2010-2013,主持。
(6) 斑马鱼肾毒性筛选模型建立及雷公藤甲素肾毒性机制研究(PY2014YW0018),中央高校基本科研业务费专项资金,时间:2014,主持。
(7) 1-磷酸鞘氨醇/1-磷酸鞘氨醇激酶通路介导的雷公藤甲素抗癌机制研究(JKQ2011014),中央高校基本科研业务费专项基金,时间:2011-2012,主持。
Li Liu, Xi Zhang, Xin Xing,Ismail Mohammed,Xiao-ting Xu, Zhen-zhou Jiang,Tao Wang, Xin Huang, Xin-zhi Wang,Lu-yong Zhang,and Li-xin Sun. Triptolide Induces Liver Injury by Regulating Macrophage Recruitment and Polarization via the Nrf2 Signaling Pathway. Oxidative Medicine and Cellular Longevity. Volume 2022,1492239.
Chunhua Jiao, Qianwen Zhang, Mengjiao Yang, Jingjing Ma, Xiaojing Zhao, Nana Tang, Mingxin Dai, Qingyu Li, Zhenzhou Jiang, Xin Huang, Hongjie Zhang, Lixin Sun.Shenling Baizhu San ameliorates ulcerative colitis by regulating the gut microbiota and its tryptophan metabolites: A complementary medicine to mesalamine. J Ethnopharmacol. 2022, 291:115145.
Liping Li , Qianwen Zhang, Xi Zhang, Xiaoting Xu, Xinzhi Wang, Xin Huang, Tao Wang, Zhenzhou Jiang, Li Xiao, Luyong Zhang, Lixin Sun. Protective effects of Nrf2 against sepsis-induced hepatic injury. Life Sci. 2021. 282, 1-9.
Shan Huang, Li Liu, Huifang Mei, Qianwen Zhang , Xi Zhang, Xiaoting Xu, Xinzhi Wang , Xin Huang, Tao Wang , Zhenzhou Jiang, Luyong Zhang, Lixin Sun. Altered integrity of hepatocyte tight junctions in rats with triptolide-induced cholestasis. Chinese Journal of Natural Medicines 2021, 19(3): 188-194.
Xu Xiaoting, Zhang xi, Yuan Yuzhu, Zhao Yongrui, Hamza M Fares, Yang Mengjiao, Wen Qing, Sun Lixin. Species-Specific Differences in Aryl Hydrocarbon Receptor Responses: How and Why?Int. J. Mol. Sci. 2021, 22(24), 13293.
Han Li, Liping Li, Huifang Mei, Guofeng Pan, Xinzhi Wang, Xin Huang, Tao Wang, Zhenzhou Jiang, Luyong Zhang & Lixin Sun. Antitumor properties of triptolide: phenotype regulation of macrophage differentiation, Cancer Biology & Therapy. 2020, 21(2), 178–188.
Han Li, Xin Xinga, Xi Zhang, Liping Li, Zhenzhou Jiang, Tao Wang, Xin Huang, Xinzhi Wang, Luyong Zhang, Lixin Sun. Effects of triptolide on the sphingosine kinase-Sphingosine-1-phosphate signaling pathway in colitis-associated colon cancer. International immunopharmacology. 2020, 88(106892).
Lu Wang, Dengqiu Xu,Liping Li,Xin Xing,Liu Li, Mohammed Ismail Abdelmotalab,Li Xiao,Tao Pang,Xin Huang,Xinzhi Wang,Tao Wang,Zhenzhou Jiang,Luyong Zhang,Lixin Sun. Possible role of hepatic macrophage recruitment and activation in triptolide-induced hepatotoxicity, Toxicol. Lett. 2018,299, 32-39.
Zhenzhou Jiang, Xiao Huang, Shan Huang, Hongli Guo, Lu Wang, Xiaojiaoyang Li, Xin Huang, Tao Wang, Luyong Zhang, Lixin Sun, Sex-Related Differences of Lipid Metabolism Induced by Triptolide,The Possible Role of the LXRalpha/SREBP-1 Signaling Pathway, Front Pharmacol, 2016, 7(87)
Han Li, Guofeng Pan, Zhen-zhou Jiang, Jing Yang, Lixin Sun and Lu-yong Zhang, Triptolide inhibits human breast cancer MCF-7 cell growth via downregulation of the ERα-mediated signaling pathway, Acta Pharmacologica Sinica, 2015, 36, 606-613
Triptolide alters barrier function in renal proximal tubular cells in rats. Sun L, Li H, Huang X, Wang T, Zhang S, Yang J, Huang S, Mei H, Jiang Z, Zhang L, Toxicology letters. 2013, 223:96-102.
Possible role of mtDNA depletion and respiratory chain defects in aristolochic acid I-induced acute nephrotoxicity. Jiang Z, Bao Q, Sun L, Huang X, Wang T, Zhang S, Li H, Zhang L, , ToxicolApplPharmacol, 2013,266:198-203.
Triptolide inhibits COX-2 expression by regulating mRNA stability in TNF-α-treated A549 cells. Sun L, Zhang S, Jiang Z, Huang X, Wang T, Huang X, Li H and Zhang L. Biochem Biophys Res Commun, 2011,416(1-2):99-105.