张凡，男，生物化学与分子生物学博士，副教授。

研究工作聚焦于神经疾病病理机制与先导药物分子发现。重点关注：1. 非成瘾性Nav1.8镇痛新药开发；2. 脑卒中与神经疾病的病理机制及新型神经保护剂；3. 离子通道与GPCRs受体的皮肤药理学。

主持承担国家自然科学基金、江苏省自然科学基金及企业委托课题；作为重要成员参与科技部重大新药创制等国家级课题。近年来以第一作者或通讯作者在国际知名期刊 Journal of Biological Chemistry、British Journal of Pharmacology、Journal of Medicinal Chemistry、Archives of Toxicology等发表研究论文多篇。申请并获得发明专利多项。担任Journal of Medicinal Chemistry、NeuroToxicology等多个国际期刊审稿人。

主讲课程

本科生：药理学、生理药理学、神经生物学概论、动物资源药物；

研究生：神经科学与疾病；

研究生招生方向：中药药理学（学硕），中药药效与安全性评价（专硕）；

学科研究方向：神经与精神疾病药理学/多肽生物化学

研究方向：

1. 小分子与活性多肽调控疼痛靶点的分子机制、结构优化及成药性研究；

2. 神经损伤性疾病（脑卒中、神经退行性疾病）的病理机制与新型神经保护剂的开发；

3. 离子通道与GPCRs受体的皮肤药理学；

欢迎有志于药理学（神经疾病病理机制研究与先导药物分子开发）研究的本科生、研究生加入课题组，共攀科学高峰！

主持科研项目：

1. 基于多肽探针的Nav1.2调节NMDA受体功能增强诱发神经毒性的机制研究，国家自然科学基金青年基金，项目号：31900905；

2. 靶向Nav1.7传统镇痛中药中抑制剂的发现及其镇痛机制研究，江苏省自然科学基金青年基金，项目号：BK20160764；

3. 一种基于心肌细胞同步钙震荡快速评价心脏毒性物质方法的建立以及在中药注射液心脏毒性预测中的应用，中央高校基本科研业务费自然科学类项目，项目号：2016ZPY020；

4. 一种基于靶向河豚毒素敏感型钠通道活性的贝类神经毒素的高通量检测方法的建立，中国科学院环境化学与生态毒理学国家重点实验室开放基金，项目号：KF2015-13；

5. 信号芋螺肽类毒素作用于疼痛相关离子通道的结构与功能的研究，中国药科大学新教师科研启动基金；

6. 动物毒素靶向疼痛相关离子通道抑制剂的发现与镇痛机制研究，中国药科大学大学生创新创业计划国家级项目；

7. 疼痛靶点TRPV2抑制剂的发现与作用机制研究，中国药科大学大学生创新创业计划省级项目；

     

近期代表性论文

1. Kaiyue Liu^#, Yunyun Ji^#, Yiming Xie^#, Chengyan Wang^#, Jie Zhou, Ziyi Wei, Xiaoyu Wang, Xiaotong Zheng, Yao Cen, Fan Zhang*, Bailing Xu*. Discovery of Isobenzofuran-1(3H)-one derivatives as selective TREK-1 inhibitors with in vitro and in vivo neuroprotective effects. Journal of Medicinal Chemistry, 2025, 68(5): 5804-5823.

2. Meihuizi Ding^#, Rui Han^#, Yiming Xie^#, Ziyi Wei^#, Shuwen Xue, Fan Zhang*, Zhengyu Cao*. Plumbagin, a novel TRPV2 inhibitor ameliorates microglia activation and brain injury in an MCAO/R mouse model. British Journal of Pharmacology, 2025, 182(1):87-103.

3. Shanshan Zhang, Na Chen, Faji Wu, Xiujin Xu, Xiaotong Zheng, Zhen Cheng, Miaofeng Wang, Yang Wu, Shuoqi Jiang, Qingmei Liu, Chenfeng Liu, Fan Zhang*, Bingnan Han*. Discovery of therapeutic promising natural products to target Kv1.3 channel, a transmembrane protein regulating immune disorders, through multidimensional virtual screening, molecular dynamics simulations and biological validation. International Journal of Biological Macromolecules, 2025, 308(Pt 2):142636.

4. Yi Kuang, Yiming Xie, Cailing Tan, Junyi Ye, Pingping Shen, Richa Raj, Fan Zhang*, Jian Zhang*. Investigation of the interaction between chrysin, apigenin, and luteolin with HMGB1 using integrated multi-spectroscopy and molecular docking methods. Food Bioscience, 2025, 63:105805.

5. 危子怡，韩蕊，谢伊铭，李芳*，张凡*，靶向Nav1.8的镇痛药物研发进展：2009-2025. 药学学报， 2025.

6. Qian Wua^#, Ruo-Xi Hua^#, Yan-Ru Han, Qian Zhua, Wan-Jin Zhang, Juan Chen, Fan Zhang, Chun-Lei Zhang*, Zheng-Yu Cao*. Four new alkaloids from the roots of Dactylicapnos scandens. Journal of Asian Natural Products Research, 2024, 26(2):248-258.

7. 韩蕊, 蔡怡琳, 郑晓彤, 林凡祺, 张凡* 靶向Nav1.7的镇痛药物开发: 临床试验进展与选择性抑制剂发现. 药学学报. 药学学报， 2024, 59(9): 2417-2428.

8. Shaoheng Li^#, Meihuizi Ding^#, Ying Wu^#, Shuwen Xue, Yunyun Ji, Pinhui Zhang, Zhuang Zhang, Zhengyu Cao*, Fan Zhang*, Histamine sensitization of the voltage-gated sodium channel Nav1.7 contributes to histaminergic itch in mice. ACS Chem Neurosci. 2022. 13(5):700-710.

9. Chun-Lei Zhang^#, Ju Liu^#, Chu-Chu Xi, Yan-Gang Cao, Jing He, Shu-Cong Li, Fan Zhang, C Benjamin Naman, Zheng-Yu Cao*, Cadinane sesquiterpenoids and their glycosides from Alangium chinense that inhibit spontaneous calcium oscillations. J Nat Prod. 2021. 85(3):599-606.

10.  Shu-wen Xue, Fan Zhang*, Zhengyu Cao*, Advances in structure and pharmacological function of temperature-sensitive TRPV2 channel. Acta Pharmaceutica Sinica, 2021, 56(10): 2720-2727.

11. Chunlei Zhang^#, Qilong Huang^#, Qian Zhu, Jing He, Juan Chen, Fan Zhang*, Zhengyu Cao*, Alkaloids from Corydalis decumbens modulate neuronal excitability. Bioorganic Chemistry, 2020, 99:103795.  

12. Chunlei Zhang^#, Qilong Huang^# , Qian Zhu, Juan Chen, Fan Zhang*, Zhengyu Cao*, New phthalideisoquinoline hemiacetal alkaloid derivatives from Corydalis decumbens. Fitoterapia, 2020,   144:104494.

13. Fan Zhang, Changxin Zhang, Xunxun Xu,Yunxiao Zhang,Xue Gong, Zuqin Yang, HengZhang, Dongfang Tang, Songping Liang*, Zhonghua Liu*, Naja atra venom peptide reduces pain by selectively blocking the voltage-gated sodium channel Nav1.8. Journal of Biological Chemistry, 2019, 294(18):7324-7334.

14. Fan Zhang^#, Ying Wu^#, Shuwen Xue, Shuangyan Wang, Chunlei Zhang*, Zhengyu Cao*, 3’-O-Methylorobol inhibits the voltage-gated sodium channel Nav1. 7 with anti-Itch efficacy in a histamine-dependent itch mouse model. International Journal of Molecular Sciences, 2019, 20(23):6058.

15. Fan Zhang^#, Ying Wu^#, Xiaohan Zou, Qinglian Tang, Fang Zhao, Zhengyu Cao*, BmK AEP, an anti-epileptic peptide distinctly affects the gating of brain subtypes of voltage-gated sodium channels, International Journal of Molecular Sciences, 2019, 20(3):729.

16. Ying Wu^#, Hui Ma^#, Fan Zhang^*, Chun-Lei Zhang, Xiaohan Zou, and Zhengyu Cao^*, Selective voltage-gated sodium channel peptide toxins from animal venom: pharmacological probes and analgesic drug development, ACS Chemical Neuroscience, 2018, 9(2):187-197.

17. Xiaohan Zou, Ying Wu, Juan Chen, Fang Zhao, Fan Zhang^*, Boyang Yu, Zhengyu Cao^*, Activation of sodium channel by a novel α-scorpion toxin, BmK NT2, stimulates ERK1/2 and CERB phosphorylation through a Ca²⁺ dependent pathway in neocortical neurons, International Journal of Biological Macromolecules, 2017, 104:70-77.

18. Yuwei He^#, Xiaohan Zou^#, Xichun Li, Juan Chen, Liang Jin, Fan Zhang^*, Boyang Yu, Zhengyu Cao^*, Activation of sodium channels by α-scorpion toxin, BmK NT1, produced neurotoxicity in cerebellar granule cells: an association with intracellular Ca²⁺ overloading. Archives of Toxicology, 2017, 91(2):935-948.

联系方式：

通讯地址：南京市江宁区龙眠大道639号，综合科研楼G455

邮政编码：211198

电子信箱：zhangfan@cpu.edu.cn