张凡，副教授，博士生导师。

主持承担国家自然科学基金面上/青年基金、江苏省自然科学基金、多项企业创新药开发项目。近年来以第一作者或通讯作者在国际知名期刊 Chemical Science、British Journal of Pharmacology、Journal of Medicinal Chemistry、Journal of Biological Chemistry 等发表研究论文多篇。申请并获得发明专利多项。担任Journal of Medicinal Chemistry、NeuroToxicology等国际期刊审稿人。

重点关注：

1.神经损伤性疾病（脑卒中、神经退行性疾病）的病理机制及新型神经保护药物；

2. 靶向离子通道（Nav1.8、Nav1.7、Nav1.9、TRPs）及GPCRs的非成瘾性镇痛（小分子、多肽、抗体）新药研究；

3. 离子通道与GPCRs的皮肤药理学；
4. 离子通道与GPCRs的AI辅助药物设计。

主讲课程

本科生：药理学、生理药理学、神经生物学；

研究生：神经科学与疾病；

研究生招生方向：中药药理与临床中药学，中药药效与安全性评价；

学科研究方向：神经与精神疾病药理学

欢迎有志于创新药研究的研究生、本科生加入课题组，共攀科学高峰！

近期代表性论文

1. Xiaotong Zheng, Xiaoyu Liu, Yuehong Yu, Tianmei Liu, Xiaolei Zhu, Yao Cen, Kai Kang*, Fan Zhang*. TRP channels in glial cells: Emerging therapeutic targets for ischemic stroke. ACS Chem Neurosci. 2026.  doi: 10.1021/acschemneuro.5c00986.

2. Kaiyue Liu^#, Yunyun Ji^#, Yiming Xie^#, Chengyan Wang^#, Jie Zhou, Ziyi Wei, Xiaoyu Wang, Xiaotong Zheng, Yao Cen, Fan Zhang*, Bailing Xu*. Discovery of Isobenzofuran-1(3H)-one derivatives as selective TREK-1 inhibitors with in vitro and in vivo neuroprotective effects. Journal of Medicinal Chemistry, 2025, 68(5): 5804-5823.

3. Meihuizi Ding^#, Rui Han^#, Yiming Xie^#, Ziyi Wei^#, Shuwen Xue, Fan Zhang*, Zhengyu Cao*. Plumbagin, a novel TRPV2 inhibitor ameliorates microglia activation and brain injury in an MCAO/R mouse model. British Journal of Pharmacology, 2025, 182(1):87-103.

4. Shanshan Zhang, Na Chen, Faji Wu, Xiujin Xu, Xiaotong Zheng, Zhen Cheng, Miaofeng Wang, Yang Wu, Shuoqi Jiang, Qingmei Liu, Chenfeng Liu, Fan Zhang*, Bingnan Han*. Discovery of therapeutic promising natural products to target Kv1.3 channel, a transmembrane protein regulating immune disorders, through multidimensional virtual screening, molecular dynamics simulations and biological validation. International Journal of Biological Macromolecules, 2025, 308(Pt 2):142636.

5. Yi Kuang, Yiming Xie, Cailing Tan, Junyi Ye, Pingping Shen, Richa Raj, Fan Zhang*, Jian Zhang*. Investigation of the interaction between chrysin, apigenin, and luteolin with HMGB1 using integrated multi-spectroscopy and molecular docking methods. Food Bioscience, 2025, 63:105805.

6. 危子怡，韩蕊，谢伊铭，李芳*，张凡*. 靶向Nav1.8的镇痛药物研发进展. 药学学报, 2026, 61(02):403-416.   

7. Qian Wua^#, Ruo-Xi Hua^#, Yan-Ru Han, Qian Zhua, Wan-Jin Zhang, Juan Chen, Fan Zhang, Chun-Lei Zhang*, Zheng-Yu Cao*. Four new alkaloids from the roots of Dactylicapnos scandens. Journal of Asian Natural Products Research, 2024, 26(2):248-258.

8. 韩蕊, 蔡怡琳, 郑晓彤, 林凡祺, 张凡*. 靶向Nav1.7的镇痛药物开发: 临床试验进展与选择性抑制剂发现.  药学学报， 2024, 59(9): 2417-2428.

9. Shaoheng Li^#, Meihuizi Ding^#, Ying Wu^#, Shuwen Xue, Yunyun Ji, Pinhui Zhang, Zhuang Zhang, Zhengyu Cao*, Fan Zhang*, Histamine sensitization of the voltage-gated sodium channel Nav1.7 contributes to histaminergic itch in mice. ACS Chem Neurosci. 2022. 13(5):700-710.

10. Chun-Lei Zhang^#, Ju Liu^#, Chu-Chu Xi, Yan-Gang Cao, Jing He, Shu-Cong Li, Fan Zhang, C Benjamin Naman, Zheng-Yu Cao*, Cadinane sesquiterpenoids and their glycosides from Alangium chinense that inhibit spontaneous calcium oscillations. J Nat Prod. 2021. 85(3):599-606.

11.  Shu-wen Xue, Fan Zhang*, Zhengyu Cao*, Advances in structure and pharmacological function of temperature-sensitive TRPV2 channel. Acta Pharmaceutica Sinica, 2021, 56(10): 2720-2727.

12. Chunlei Zhang^#, Qilong Huang^#, Qian Zhu, Jing He, Juan Chen, Fan Zhang*, Zhengyu Cao*, Alkaloids from Corydalis decumbens modulate neuronal excitability. Bioorganic Chemistry, 2020, 99:103795.  

13. Chunlei Zhang^#, Qilong Huang^# , Qian Zhu, Juan Chen, Fan Zhang*, Zhengyu Cao*, New phthalideisoquinoline hemiacetal alkaloid derivatives from Corydalis decumbens. Fitoterapia, 2020,   144:104494.

14. Fan Zhang, Changxin Zhang, Xunxun Xu,Yunxiao Zhang,Xue Gong, Zuqin Yang, HengZhang, Dongfang Tang, Songping Liang*, Zhonghua Liu*, Naja atra venom peptide reduces pain by selectively blocking the voltage-gated sodium channel Nav1.8. Journal of Biological Chemistry, 2019, 294(18):7324-7334.

15. Fan Zhang^#, Ying Wu^#, Shuwen Xue, Shuangyan Wang, Chunlei Zhang*, Zhengyu Cao*, 3’-O-Methylorobol inhibits the voltage-gated sodium channel Nav1. 7 with anti-Itch efficacy in a histamine-dependent itch mouse model. International Journal of Molecular Sciences, 2019, 20(23):6058.

16. Fan Zhang^#, Ying Wu^#, Xiaohan Zou, Qinglian Tang, Fang Zhao, Zhengyu Cao*, BmK AEP, an anti-epileptic peptide distinctly affects the gating of brain subtypes of voltage-gated sodium channels, International Journal of Molecular Sciences, 2019, 20(3):729.

17. Ying Wu^#, Hui Ma^#, Fan Zhang^*, Chun-Lei Zhang, Xiaohan Zou, and Zhengyu Cao^*, Selective voltage-gated sodium channel peptide toxins from animal venom: pharmacological probes and analgesic drug development, ACS Chemical Neuroscience, 2018, 9(2):187-197.

18. Xiaohan Zou, Ying Wu, Juan Chen, Fang Zhao, Fan Zhang^*, Boyang Yu, Zhengyu Cao^*, Activation of sodium channel by a novel α-scorpion toxin, BmK NT2, stimulates ERK1/2 and CERB phosphorylation through a Ca²⁺ dependent pathway in neocortical neurons, International Journal of Biological Macromolecules, 2017, 104:70-77.

19. Yuwei He^#, Xiaohan Zou^#, Xichun Li, Juan Chen, Liang Jin, Fan Zhang^*, Boyang Yu, Zhengyu Cao^*, Activation of sodium channels by α-scorpion toxin, BmK NT1, produced neurotoxicity in cerebellar granule cells: an association with intracellular Ca²⁺ overloading. Archives of Toxicology, 2017, 91(2):935-948.

联系方式：

通讯地址：南京市江宁区龙眠大道639号

邮政编码：211198

电子信箱：zhangfan@cpu.edu.cn