江峰
学术硕士生导师
职称:副教授
15150650803
学院:工学院
jiangfeng@cpu.edu.cn
招生学科:生物与医药-制药工程与工艺,制药工程学
个人简介

 (一)教学工作:

1、主讲本科生课程《制药工程制图》、研究生课程《高等合成技术》。

2、主编教材《制药工程制图》和《制药工程制图习题集》(第三版,化学工业出版社,2021年),参编教材8本。

3、主持2024年全国药学专业学位研究生精品课程-《高等合成技术》,主持校级教改课题:2022年研究生精品课程-《高等合成技术》、2022年研究生专业学位课程改革项目-《高等合成技术》、2021年基于“培养解决复杂问题能力”的教学内容和方法改革研究。

4、作为指导教师荣获2024年江苏省研究生医药科研创新实践大赛二等奖、2024江苏省第五届大学生生物医学工程创新设计竞赛三等奖、2023年第八届全国大学生生命科学竞赛三等奖、2022“东富龙-国药工程杯”第十届全国大学生制药工程设计竞赛三等奖,个人荣获2022中国药科大学微课教学比赛三等奖2018年澳天力奖教金一等奖。

5、担任本科生导师3次,指导大学生创新创业计划项目11次。

(二)科研工作:

1、科研方向:(1)生物活性天然产物的分子优化、虚拟筛选和体内外评价;(2)药物合成新方法和新工艺研究;(3)基于活性药物分子开展药物新剂型和新功能研究。

2、科研项目:作为项目负责人,主持国家重大新药创制科技重大专项课题(2019)、江苏省自然科学基金面上和青年项目(2020、2013)、“天然药物活性组分与药效国家重点实验室优秀青年学者基金(2015)、中央高校基本科研业务费基金重点和青年项目(2018、2011)、企业委托横向项目(2024、2023、2022、2021)等,参与国家重点研发计划和国家自然科学基金项目数项。

3、科研成果:最近以通讯作者身份,在国际知名学术期刊 Journal of Controlled Release(IF=10.5), Carbohydrate Polymers (IF=11.2), Cellular and Molecular Life Sciences (IF=9.2), Biomaterials Science (IF=7.6), European Journal of Medicinal Chemistry (IF=7.1), Journal of Enzyme Inhibition and Medicinal Chemistry (IF=5.8), Bioorganic Chemistry (IF=5.3),Langmuir (IF=4.3)发表科研论文多篇,授权中国发明专利7项。

最近发表的科研论文:

1.        Xiaomeng Zhu1, Shihang Li1, Jiahui Huang1, Chengjing Yin, Yanting Li, Wei Guo*, Feng Jiang*, Feng Cao*. FRET-based analysis on the fate of liposome and cyclodextrin@liposome nanocomposites from ocular surface to the posterior segment of the eye. Journal of Controlled Release, 2025, 377, 794-809.

2.        Haoyi Yang1, Dongyu Zhang1, Ziyang Yuan1, Haishi Qiao, Zhuolu Xia, Feng Cao*, Yuanyuan Lu*, Feng Jiang*. Novel 4-Aryl-4H-chromene derivative displayed excellent in vivo anti-glioblastoma efficacy as the microtubule-targeting agent. European Journal of Medicinal Chemistry, 2024, 267, 116205.

3.        Jinhui Lu1, Xiaomeng Zhu1, Meng Zhang1, Xunchan Jiang, Wei Guo*, Feng Jiang*, Feng Cao*.In vitro and in vivo assessment of structural integrity for HPCD complex@Liposome nanocomposites from ocular surface to the posterior segment of the eye. Carbohydrate Polymers, 2023, 315, 120960.

4.   Chunhua Zhang, Qifan Ding, Zhuolu Xia, Hengyu Wang, Feng Jiang* and Yuanyuan Lu*. Novel Chalcone-Phenazine Hybrids Induced Ferroptosis in U87-MG Cells through Activating Ferritinophagy. Chemistry & Biodiversity, 2023, 20, e202201117.

5.        Yue Yang1, Yuanyuan Lu1, Chunhua Zhang1, Qianqian Guo, Wenzhou Zhang, Ting Wang, Zhuolu Xia, Jing Liu, Xiangyu Cheng, Tao Xi*, Feng Jiang*, Lufeng Zheng*. Phenazine derivatives attenuate the stemness of breast cancer cells through triggering ferroptosis. Cellular and Molecular Life Sciences2022, 79: 360.

6.        Jing Liu, Youqiao Xu, Haojie Lu, Rong Wang, Zhuolu Xia, Changshun Zhao, Dechun Huang*, Feng Jiang*Wei Chen. Nanoaggregates of Disulfide-Decorated TrxR Inhibitor Promote Cellular Uptake, Selective Targeting, and Antitumor Efficacy. Langmuir2022, 38, 13955-13962.

7.        Haojie Lu, Jing Liu, Meizhe Yu, Peili Li, Ruobing Huang, Wenzhen Wu, Zunhan Hu, Yuhong Xiao,* Feng Jiang* and Xiaodong Xing*. Photothermal-enhanced antibacterial and antioxidant hydrogel dressings based on catechol-modified chitosan-derived carbonized polymer dots for effective treatment of wound infection. Biomaterials Science2022, 10, 2692-2705.

8.        Yuanyuan Song, Ziqi Wang, Yijing Long, Yang Mao, Feng Jiang*, Yuanyuan Lu*. 2-Alkyl-anthraquinones inhibit Candida albicans biofilm via inhibiting the formation of matrix and hyphae. Research in Microbiologoy2022, 173, 103955.

9.        刘静, 徐幼桥, 张春花, 夏卓璐, 王志祥, 黄德春江峰*吩嗪及其类似物抗肿瘤活性研究进展药学进展2022, 46(9): 710-722.

10.    Yucheng Zhong1, Jing Liu1, Xiangyu Cheng, Hao Zhang, Chunhua Zhang, Zhuolu Xia, Zhongxi Wu, Lu Zhang, Yuting Zheng, Zhanyu Gao, Zhidong Jiang, Zhixiang Wang, Dechun Huang, Yuanyuan Lu*, Feng Jiang*. Design, synthesis and biological evaluations of diverse Michael acceptor-based phenazine hybrid molecules as TrxR1 inhibitors. Bioorganic Chemistry2021, 109, 104736.

11.    Jing Liu1, Fei Ji1, Zhuolu Xia, Chunhua Zhang, Changshun Zhao, Yanfei Li, Xiang Zhou, Dechun Huang, Wei Chen*, Feng Jiang*. Multifunctional nanoaggregates composed of active CPUL1 and a triphenylphosphine derivative for mitochondria-targeted drug delivery and cell imaging. ChemMedChem2021, 16, 1-6.

12.    Dechun Huang, Zhonglin Zhu, Qiming Wang, Beichen Qin, Lin Dai, Feng Jiang, Wei Liu*, Hongliang Qian*. Prediction model, experimental optimization, and verification for yield of high-pressure crystallization: a case study of citric acid. Separation Science and Technology2020, 55(1): 135-143.

13.    Jianming Liao, Linlin Wang, Zhongxi Wu, Zhixiang Wang, Jun Chen, Yucheng Zhong, Feng Jiang*, Yuanyuan Lu*. Identification of phenazine analogue as a novel scaffold for thioredoxin reductase I inhibitors against HepG2 cancer cell lines. Journal of Enzyme Inhibition and Medicinal Chemistry2019, 34(1): 1158-1163.

14.    Meichen Zhang, Shuhui Gu, Guangpan Liu, Chencheng Li, Hanmei Xu*, Zhongxi Wu, Boping Ye, Yuanyuan Lu, Dechun Huang, Zhixiang Wang, Feng Jiang*. Facile synthesis and cytotoxicity of phenazine-chromene hybrid molecules derived from phenazine natural product. Combinatorial Chemistry & High Throughput Screening2019, 22(1): 35-40.

15.    Jing Zhang, Qiming Wang, Zhonglin Zhu, Hongliang Qian, Feng Jiang, Zhixiang Wang, Wei Liu*, Dechun Huang*. Micronization of gefitinib using solution‐enhanced dispersion by supercritical CO2Chemical Engineering & Technology2019, 42(2): 388-396.

16.    Hongliang Qian, Lin Dai, Feng Jiang, Yiqiang Shi, Zhixiang Wang, Wei Liu*, Dechun Huang*, Wei Chen. Quantitative design of seed load based on model identification of nucleation and crystal growth stages without transmittance data. Powder Technology2018, 335, 11-17.

17.    Yuanyuan Lu, Yuru Yan, Linlin Wang, Xiaobing Wang, Jing Gao, Tao Xi, Zhixiang Wang, Feng Jiang*. Design, facile synthesis and biological evaluations of novel pyrano[3,2-a]phenazine hybrid molecules as antitumor agents. European Journal of Medicinal Chemistry2017, 127, 928-943.

18.    Yuanyuan Lu*, Linlin Wang, Xiaobing Wang, Tao Xi, Jianmin Liao, Zhixiang Wang, Feng Jiang*. Design, combinatorial synthesis and biological evaluations of novel 3-amino-1′-((1-aryl-1H-1,2,3-triazol-5-yl)methyl)-2′-oxospiro[benzo[a] pyrano[2,3-c]phenazine-1,3′-indoline]-2-carbonitrile antitumor hybrid molecules. European Journal of Medicinal Chemistry2017, 135, 125-141.

授权发明专利:

1.      江峰, 王荣, 刘静等二硫键修饰的纳米聚集体及其制备方法和应用中国发明专利2022111500513. 

2.      江峰, 夏卓璐, 张东宇等. 吡喃并喹啉衍生物及其制备方法和应用. 中国发明专利2022106500674. 

3.      江峰, 王荣, 陆园园等. 一种查尔酮吩嗪杂化分子及其应用. 中国发明专利2022106290021. 

4.      江峰, 刘静, 黄德春等. 一种纳米聚集体及其制备方法和应用. 中国发明专利2021109114648. 

5.      江峰, 吴仲稀, 王志祥等. 作为TrxR1抑制剂的吩嗪衍生物、中间产物及其制备方法和用途. 中国发明专利2019104264957. 

6.      江峰闫玉茹, 陆园园等. 一种吡喃并[3,2-a]吩嗪衍生物及其制备方法和用途. 中国发明专利2015108940700. 

7.      陆园园, 丁启帆江峰. CPUL1脂质体及其制备方法. 中国发明专利2021104939593. 

 


 

个人经历
科研项目
科研专利
发表论文
获奖成果
教材专著

研究方向

(1)生物活性天然产物的分子优化、虚拟筛选和体内外评价;(2)药物合成新方法和新工艺研究;(3)基于活性药物分子开展药物新剂型和新功能研究。