司马健，教授，博士生导师。2019年入职中国药科大学，入选 ”江苏特聘教授“、中国药科大学“药学拔尖创新人才培养计划”导师。2009年博士毕业于中科院上海神经科学研究所；2009-2012，于国际制药企业GSK药物研发中心任职研发科学家，主持参与多项神经退行疾病相关药物研发项目，曾获得GSK FIRST创新奖；2012-2018，于美国国立健康研究院（NIH）衰老研究所（NIA）从事博士后研究，开展分子遗传学以及神经退行性疾病的靶点鉴定及药物开发等研究，期间连续三次获得NIH FARE奖，以及一次NIA年度所长奖；2018-2019，在美国南加州大学Alzheimer’s Disease Center任 Research associate，从事阿尔茨海默症的新靶点发现及临床试验相关研究。近年以通讯作者（含共同通讯）在Science Advances、Cell Reports、PNAS、Genome Biology、Development、Cell & Bioscience等期刊发表了论文，并任Plos Aging and Health、Aging Research编委（Editorial Board)。主持国家自然科学基金、江苏特聘教授基金、校企联合创新药重大项目等。指导研究生连续3年获得“江苏省研究生科研实践创新计划”立项资助。目前课题组平台搭建成熟，欢迎有志青年报考硕博研究生。

代表性论文：

1. Wu J, Lu X, Zhang J, Wang S, Lu Z, Han Y, Yang R, Su Y, Tan C, Huo D, Liu U.Y*, Sima J*.  Astrocytic AEBP1-NPAS3-LIPA pathway coordinates cholesterol homeostasis to regulate Alzheimer's pathology. Cell Reports, 2026. 

2. Yang R, Wang L, Li Y, Zhu J, Wang J, Schlessinger D, Sima J*. DKK3-LRP1 complex and a chemical inhibitor regulate Aβ clearance in models of Alzheimer’s disease. Science Advances, 2025. 

3. Ma T, Li YM, Ren PY, Wang SQ, Liu XL, Lv WB, Hou WG, Zuo WQ, Lin WQ, Sima J*, Geng AQ*. DNA2 knockout aggravates cerebral ischemia/reperfusion injury by reducing postsynaptic Homer1a. Zoological Research, 2025. 

4. Xu C, Cao J, Qiang H, Liu Y, Wu J, Luo Q, Wan M, Wang Y, Wang P, Cheng Q, Zhou G, Sima J*, Guo Y*, Xu S*. TaqTth-hpRNA: a novel compact RNA-targeting tool for specific silencing of pathogenic mRNA. Genome Biology, 2024. 

5. Xu C, Mei Y, Yang R, Luo Q, Zhang J, Kou X, Hu J, Wang Y, Li Y, Chen R, Zhang Z*, Yao Y*, Sima J*. Edaravone Dexborneol mitigates pathology in animal and cell culture models of Alzheimer's disease by inhibiting neuroinflammation and neuronal necroptosis. Cell and Bioscience, 2024.  

6. Yao Y, Yang R, Zhu J, Schlessinger D, Sima J*. EDA ligand triggers plasma membrane trafficking of its receptor EDAR via PKA activation and SNAP23-containing complexes. Cell and Bioscience, 2023.  

7. Yao Y#, Ren Z#, Yang R, Mei Y, Dai Y, Cheng Q, Xu C, Xu X, Wang S, Kim KM, Noh JH, Zhu J, Zhao N, Liu YU, Mao G*, Sima J*. Salidroside reduces neuropathology in Alzheimer’s disease models by targeting NRF2/SIRT3 pathway. Cell and Bioscience, 2022.  

8. Sima J#*, Yan Z#, Chen Y, Lehrmann E, Zhang Y, Nagaraja R, Wang W, Wang Z, Schlessinger D*. Eda-activated RelB recruits a SWI/SNF (BAF) chromatin remodeling complex and initiates gene transcription in skin appendage formation.  PNAS, 2018.  (*Corresponding author)  

9. Sima J*, Piao Y, Chen Y, Schlessinger D*. Molecular dynamics of Dkk4 modulates Wnt action and regulates meibomian gland development. Development, 2016.  (*Corresponding author)

10. Chen G#, Sima J#, Jin M#, Wang KY, Xue XJ, Zheng W, Ding YQ, Yuan XB.  Semaphorin-3A guides radial migration of cortical neurons during development. Nature Neuroscience, 2008. (# Co-first author)  

奖励/荣誉：

2022, 入选“江苏特聘教授”

2017, NIH Fellows Award for Research Excellence

2016, NIH Fellows Award for Research Excellence

2015, NIH Fellows Award for Research Excellence

2014, NIA Annual Scientific Director Award

2011, GSK FIRST (Forum for Innovative Research and Scientific Talents) Award