储卫华，男，博士，中国药科大学生命科学与技术学院微生物与合成生物学系副教授，微生物与生化药学、生物学、生物与医药（专业学位）、药学（专业学位）硕士生导师,指导的多名研究生获得国家奖学金，1名学生论文获得江苏省优秀硕士论文。现任BMC Microbiology, Frontiers in Microbiology等多个国际期刊编委，美国国科学研究荣誉学会(Sigma Xi,英文全称:The Scientific Research Honor Society)正式会员，中国微生物学会永久会员，美国微生物学会会员，国际应用微生物学会会员，中华预防医学会微生态学专业委员会中医药微生态学组委员，江苏省生物化学学会会员, 江苏省环境科学学会环境生物技术委员会委员，2021年-2025年连续5年入选全球前2%顶尖科学家榜单。南京农业大学国家重点学科动物医学博士毕业；曾在南京理工大学化工学院生物工程系、美国德州州立大学生物学系从事博士后研究。主要从事微生物与免疫学、生物制药方面的教学与科研工作。先后主持或参与国家863计划、国家自然科学基金面上项目、江苏省三项工程、江苏省、浙江省自然科学基金、国家质检总局等课题10余项，作为发明人申请国家发明专利15项，获得授权8项；发表论文100余篇，其中SCI收录80余篇。

研究方向与兴趣：

1、功能性益生菌发现与应用、微生物组与健康

2、微生物天然产物药物发现及合成生物学研究

3、环境污染物与健康

主持的代表性科研项目：

1、国家自然科学基金面上项目“基于“群体感应-肠道菌群-肠上皮细胞”途径探讨产淬灭酶芽孢菌干预嗜水气单胞菌感染鲫鱼作用机制”。

2、国家高技术研究发展计划（863计划）子课题“基因工程胶原蛋白生产菌副产物高品质饲料的开发”。

3、江苏省科技创新项目“基于菌群结构高通量测序分析的池塘微生物修复剂的研发与示范”。

4、江苏省自然科学基金“基于细菌群体感应系统高效微生态制剂的研制”。

5、专利成果转化：一种载氧负菌固定化微球制备方法及其应用。

6、专利成果转化：一株具有抗菌抗氧化活性魏斯氏菌菌株及应用。

近五年发表学术论文：

1、  Shuaiwen Li, Zihui Chen, Minyu Wang, Yao Rao, Feng Yang, Mei Liu, Weihua Chu*, Wanqing Yue*. L-Arginine-Modified Selenium Nanozymes Targeting M1 Macrophages for Oral Treatment of Ulcerative Colitis. Small. 2025, 21(6):e2408205. doi: 10.1002/smll.202408205.

2、Yao Y, Zhang Y, Xue B, Chu W*. Attenuation of MEHP-induced hepatotoxicity and gut microbiota dysbiosis by Lactobacillus brevis Lb-0401 in Carassius auratus. Sci Total Environ. 2025, 999:180328. doi: 10.1016/j.scitotenv.2025.180328. 

3、Bai X, Shi P, Chu W*. Probiotic attributes, antioxidant and neuromodulatory effects of GABA-Producing Lactiplantibacillus plantarum SY1 and optimization of GABA production. BMC Microbiol. 2025, 25(1):341. doi: 10.1186/s12866-025-04070-9.

4、Zhou S, Wen X, Lessing DJ, Chu W*. Uric Acid-Degrading Lacticaseibacillus paracasei CPU202306 Ameliorates Hyperuricemia by Regulating Uric Acid Metabolism and Intestinal Microecology in Mice. Probiotics Antimicrob Proteins. 2025, doi: 10.1007/s12602-025-10532-3.

5、Bai X, Wang M, Xu T, Zhou S, Chu W*. Antioxidant and anti-aging activities of Acanthopanax senticosus polysaccharide CQ-1 in nematode Caenorhabditis elegans. Int J Biol Macromol. 2025, 297:139925. doi: 10.1016/j.ijbiomac.2025.139925.

6、Zhou S, Wen X, Zhao Y, Bai X, Qin X, Chu W*. Structural elucidation of a Acanthopanax senticosus polysaccharide CQ-1 and its hepatoprotective activity via gut health regulation and antioxidative defense. Int J Biol Macromol. 2024，281(Pt 1):136343. doi: 10.1016/j.ijbiomac.2024.

7、Yang Zhao, Shipo Li, Duncan James Lessing, Weihua Chu*. The attenuating effects of synbiotic containing Cetobacterium somerae and Astragalus polysaccharide against trichlorfon-induced hepatotoxicity in crucian carp (Carassius carassius). Journal of Hazardous Materials 2024, 461: 132621

8、Jinqiu Liu, Wei Zhu, Duncan James Lessing, Weihua Chu*. Synthetic microbial consortia for the treatment of Clostridioides difficile infection in mice model. Microbial Biotechnology. 2023; 16(10):1985-2006.

9、Xin Wen, Huazhong Yang, Zhongqi Li, Weihua Chu*. Alcohol degradation, learning, and memory-enhancing effect of Acetobacter pasteurianus BP2201 in Caenorhabditis elegans model. Journal of Applied Microbiology, 2023, 134, 1–10 https://doi.org/10.1093/jambio/lxad253.

10、           Xin Wen, Zheng Wang, Qi Liu, Duncan James Lessing, Weihua Chu*. Acetobacter pasteurianus BP2201 alleviates alcohol-induced hepatic and neuro-toxicity and modulate gut microbiota in mice. Microbial Biotechnology. 2023; 16(9): 1834-1857.

11、           Yunxia Li, Wei Zhu, Yan Jiang, Duncan James Lessing and Weihua Chu*. Synthetic bacterial consortia transplantation for the treatment of Gardnerella vaginalis-induced bacterial vaginosis in mice. Microbiome. 2023, 11:54 https://doi.org/10.1186/s40168-023-01497-y.

12、           Minyu Wang, Zheng Wang, Duncan James Lessing, Min Guo, and Weihua Chu*. Fusobacterium nucleatum and its metabolite hydrogen sulfide alter gut microbiota composition and autophagy process and promote colorectal cancer progression. Microbiology spectrum, 2023, e0229223, DOI: 10.1128/spectrum.02292-23.

13、           Wu W, Liu W, Wang H, Wang W, Chu W^#*, Jin J^#*. β-sitosterol inhibits trimethylamine production by regulating the gut microbiota and attenuates atherosclerosis in ApoE^-/- mice. Front Cardiovasc Med. 2022; 9:986905. doi: 10.3389/fcvm.2022.986905.

14、           Gao M, Heng X, Jin J, Chu W*. Gypenoside XLIX Ameliorate High-Fat Diet-Induced Atherosclerosis via Regulating Intestinal Microbiota, Alleviating Inflammatory Response and Restraining Oxidative Stress in ApoE^-/- Mice. Pharmaceuticals (Basel). 2022，15(9):1056. doi: 10.3390/ph15091056.

15、           Zhou S, Zhu W, Qin X, Li S, Chu W*. Synthesis and Evaluation of Antioxidant and Potential Prebiotic Activities of Acetylated and Butyrylated Fructo-Oligosaccharides. Antioxidants (Basel). 2022,11(9):1658. doi: 10.3390/antiox11091658.

16、           Liu B, Ding Z, Xiong J, Heng X, Wang H*, Chu W*. Gut Microbiota and Inflammatory Cytokine Changes in Patients with Ankylosing Spondylitis. Biomed Res Int. 2022，2022:1005111. doi: 10.1155/2022/1005111.

17、           Wang Z, Wang W, Zhu C, Gao X, Chu W*. Evaluation of Antioxidative and Neuroprotective Activities of Total Flavonoids From Sea Buckthorn (Hippophae rhamnoides L.). Front Nutr. 2022,9:861097. doi: 10.3389/fnut.2022.86109.

18、           Wugao Liu, Shuxin Zhou, Wang Wei, De Lin and Weihua Chu*. Characterization of Urethritis-Associated Neisseria meningitidis isolated from Men Who Have Sex with Women in China. Journal of Infection. 2022, 84(5): e87-e88. DOI: 10.1016/j.jinf.2022.01.025

19、           Xin Pei, Xing Heng and Weihua Chu*. Polystyrene nano/microplastics induce microbiota dysbiosis, oxidative damage, and innate immune disruption in zebrafish. Microbial Pathogenesis. 2022, 163, 105387.

20、           Shipo Li, Xing Heng, Liyun Guo, Duncan James Lessing and Weihua Chu*. SCFAs improve disease resistance via modulate gut microbiota, enhance immune response and increase antioxidative capacity in the host. Fish & Shellfish Immunology. 2022. 120:560-568.

21、            Wenqian Wang, Shipo Li, Xing Heng, Weihua Chu*. Weissella confusa CGMCC 19,308 strain protects against oxidative stress, increases lifespan, and bacterial disease resistance in Caenorhabditis elegans. Probiotics and Antimicrobial Proteins. 2022, 14:121–129. DOI: 10.1007/s12602-021-09799-z.

22、           Xiao-Ying Hou, Pei Zhang, Hong-Zhi Du, Yi-Qiao Gao, Rui-Qi Sun, Si-Yuan Qin, Yuan Tian, Jing Li, Yu-Xin Zhang, Wei-Hua Chu*, Zun-Jian Zhang*, Feng-Guo Xu* Prevotella contributes to individual response of FOLFOX in colon cancer. Clinical and Translational Medicine.  2021,10.1002/ctm2.512.

23、           Shipo Li and Weihua Chu*. Influence of butyrate on the pathogenicity of Aeromonas hydrophila. Aquaculture Nutrition. 2021, 27(S1):13– 19. DOI: 10.1111/anu.13318

24、           Wang Z, Zhao Y, Jiang Y and Chu W*. Prebiotic, antioxidant, and immunomodulatory properties of acidic exopolysaccharide from marine Rhodotorula RY1801. Frontiers in Nutrition. 2021，8:710668. doi: 10.3389/fnut.2021.710668.

25、           Xianjin Qin, Wenqian Wang and Weihua Chu*. Antioxidant and reducing lipid accumulation effects of rutin in Caenorhabditis elegans. Biofactors. 2021, 47(4): 686-693, DOI: 10.1002/biof.1755.

26、           Xing Heng, Yuanhe Jiang, Weihua Chu*. Influence of fluconazole administration on gut microbiome, intestinal barrier and immune response in mice. Antimicrobial agents and chemotherapy.2021, 65(6): e02552-20, DOI: 10.1128/AAC.02552-20.

27、           Xing Heng, Wugao Liu and Weihua Chu*. Identification of choline-degrading bacteria from healthy human feces and used for screening of trimethylamine (TMA)-lyase inhibitors. Microbial Pathogenesis. 2021,152, 104658, DOI: 10.1016/j.micpath.2020.104658.

28、           Jiali Tang#, Wenqian Wang#, Yuanhe Jiang and Weihua Chu*. Diazinon exposure produces histological damage, oxidative stress, immune disorders and gut microbiota dysbiosis in crucian carp (Carassius auratus gibelio). Environmental Pollution, 2021, 269: 116129. DOI: 10.1016/j.envpol.2020.116129.

29、            Jiali Tang, Wenqian Wang and Weihua Chu*. Antimicrobial and anti-quorum sensing activities of phlorotannins from seaweed (Hizikia fusiforme). Front. Cell. Infect. Microbiol. 2020, 10:586750. DOI: 10.3389/fcimb.2020.586750.

30、           Wugao Liu, Hongji Lu, Xinyu, Chu, Tianzheng Lou, Ning Zhang, Bao Zhang and Weihua Chu*.  Tea polyphenols inhibits biofilm formation, attenuates the quorum sensing-controlled virulence and enhances resistance to Klebsiella pneumoniae infection in Caenorhabditis elegans model. Microbial Pathogenesis. 2020, 147, 104266. DOI：10.1016/j.micpath.2020.104266.

31、           Xiyi Zhuang，An Zhang，Weihua Chu*. Anti-quorum sensing activity of Forsythia suspense extract against Chromobacterium violaceum by targeting CviR receptor. International Microbiology.  2020, 23: ? 215-224. DOI: 10.1007/s10123-019-00091-3.

32、            Wei Zhu，Shuxin Zhou，Weihua Chu*. Comparative proteomic analysis of sensitive and multi-drug resistant Aeromonas hydrophila isolated from diseased fish. Microbial Pathogenesis.  2020, 139, 103930.  DOI: 10.1016/j.micpath.2019.103930.

33、           Wenqian Wang，Wugao Liu, Weihua Chu*. Isolation and preliminary screening of potentially probiotic Weissella confusa strains from healthy human feces by culturomics. Microbial Pathogenesis. 2020, 147, 104356, DOI：10.1016/j.micpath.2020.104356.

34、           Huafu Wang，Xianjin Qin, Zhihong Gui, Weihua Chu* The effect of Bailemian on neurotransmitters and gut microbiota in p-chlorophenylalanine induced insomnia mice. Microbial Pathogenesis. 2020， 148，104474，DOI:10.1016/j.micpath.2020.104474.

35、            Haichao Zhao，Xueyuan Jiang，Weihua Chu*. Shifts in the gut microbiota of mice in response to dexamethasone administration. International Microbiology. 2020, 23, 565–573, DOI: 10.1007/s10123-020-00129-x.

36、            Yuanhe Jiang，Shuxin Zhou，Emmanuel Konadu Sarkodie，Weihua Chu* The effects of Bacillus cereus QSI-1 on intestinal barrier function and mucosal gene transcription in Crucian carp (Carassius auratus gibelio). Aquaculture Reports. 2020, 17, 100356, DOI: 10.1016/j.aqrep.2020.100356.

37、           Wei Zhu, Shuxin Zhou, Jihua Liu, Robert J.C. McLean and Weihua Chu*. Prebiotic, immuno-stimulating and gut microbiota-modulating effects of Lycium barbarum polysaccharide. Biomedicine & Pharmacotherapy. 2020, 121, 109591, DOI: 10.1016/j.biopha.2019.109591.