储卫华，男，博士，中国药科大学生命科学与技术学院药物系统生物学系副教授，微生物与生化药学、公共卫生与预防医学、生物与医药专业硕士生导师。中国微生物学会永久会员，美国微生物学会会员，国际应用微生物学会会员，江苏省生物化学学会会员。南京农业大学国家重点学科动物医学博士毕业；曾在南京理工大学化工学院生物工程系、美国德州州立大学生物学系从事博士后研究。主要从事微生物与免疫学、生物制药方面的教学与科研工作。先后主持或参与国家863计划、国家自然科学基金项目、江苏省三项工程、江苏省自然科学基金、国家质检总局等课题10余项，作为发明人申请国家发明专利15项，获得授权8项；发表论文100余篇，其中SCI收录80余篇。

研究方向与兴趣：

1、益生菌、微生物组与健康

2、环境污染物与健康

3、细菌耐药性及非抗生素抗感染药物筛选及机制

近五年发表的代表性论文：

      1、  Yang Zhao, Shipo Li, Duncan James Lessing, Weihua Chu*. The attenuating effects of synbiotic containing Cetobacterium somerae and Astragalus polysaccharide against trichlorfon-induced hepatotoxicity in crucian carp (Carassius carassius). Journal of Hazardous Materials 2024, 461: 132621

2、  Jinqiu Liu, Wei Zhu, Duncan James Lessing, Weihua Chu*. Synthetic microbial consortia for the treatment of Clostridioides difficile infection in mice model. Microbial Biotechnology. 2023; 16(10):1985-2006.

3、  Xin Wen, Huazhong Yang, Zhongqi Li, Weihua Chu*. Alcohol degradation, learning, and memory-enhancing effect of Acetobacter pasteurianus BP2201 in Caenorhabditis elegans model. Journal of Applied Microbiology, 2023, 134, 1–10 https://doi.org/10.1093/jambio/lxad253.

4、  Xin Wen, Zheng Wang, Qi Liu, Duncan James Lessing, Weihua Chu*. Acetobacter pasteurianus BP2201 alleviates alcohol-induced hepatic and neuro-toxicity and modulate gut microbiota in mice. Microbial Biotechnology. 2023; 16(9): 1834-1857.

5、  Yunxia Li, Wei Zhu, Yan Jiang, Duncan James Lessing and Weihua Chu*. Synthetic bacterial consortia transplantation for the treatment of Gardnerella vaginalis-induced bacterial vaginosis in mice. Microbiome. 2023, 11:54 https://doi.org/10.1186/s40168-023-01497-y.

6、  Minyu Wang, Zheng Wang, Duncan James Lessing, Min Guo, and Weihua Chu*. Fusobacterium nucleatum and its metabolite hydrogen sulfide alter gut microbiota composition and autophagy process and promote colorectal cancer progression. Microbiology spectrum, 2023, e0229223, DOI: 10.1128/spectrum.02292-23.

7、  Wu W, Liu W, Wang H, Wang W, Chu W^#*, Jin J^#*. β-sitosterol inhibits trimethylamine production by regulating the gut microbiota and attenuates atherosclerosis in ApoE^-/- mice. Front Cardiovasc Med. 2022; 9:986905. doi: 10.3389/fcvm.2022.986905.

8、  Gao M, Heng X, Jin J, Chu W*. Gypenoside XLIX Ameliorate High-Fat Diet-Induced Atherosclerosis via Regulating Intestinal Microbiota, Alleviating Inflammatory Response and Restraining Oxidative Stress in ApoE^-/- Mice. Pharmaceuticals (Basel). 2022，15(9):1056. doi: 10.3390/ph15091056.

9、  Zhou S, Zhu W, Qin X, Li S, Chu W*. Synthesis and Evaluation of Antioxidant and Potential Prebiotic Activities of Acetylated and Butyrylated Fructo-Oligosaccharides. Antioxidants (Basel). 2022,11(9):1658. doi: 10.3390/antiox11091658.

10、             Liu B, Ding Z, Xiong J, Heng X, Wang H*, Chu W*. Gut Microbiota and Inflammatory Cytokine Changes in Patients with Ankylosing Spondylitis. Biomed Res Int. 2022，2022:1005111. doi: 10.1155/2022/1005111.

11、            Wang Z, Wang W, Zhu C, Gao X, Chu W*. Evaluation of Antioxidative and Neuroprotective Activities of Total Flavonoids From Sea Buckthorn (Hippophae rhamnoides L.). Front Nutr. 2022,9:861097. doi: 10.3389/fnut.2022.86109.

12、             Wugao Liu, Shuxin Zhou, Wang Wei, De Lin and Weihua Chu*. Characterization of Urethritis-Associated Neisseria meningitidis isolated from Men Who Have Sex with Women in China. Journal of Infection. 2022, 84(5): e87-e88. DOI: 10.1016/j.jinf.2022.01.025

13、             Xin Pei, Xing Heng and Weihua Chu*. Polystyrene nano/microplastics induce microbiota dysbiosis, oxidative damage, and innate immune disruption in zebrafish. Microbial Pathogenesis. 2022, 163, 105387.

14、             Shipo Li, Xing Heng, Liyun Guo, Duncan James Lessing and Weihua Chu*. SCFAs improve disease resistance via modulate gut microbiota, enhance immune response and increase antioxidative capacity in the host. Fish & Shellfish Immunology. 2022. 120:560-568.

15、             Wenqian Wang, Shipo Li, Xing Heng, Weihua Chu*. Weissella confusa CGMCC 19,308 strain protects against oxidative stress, increases lifespan, and bacterial disease resistance in Caenorhabditis elegans. Probiotics and Antimicrobial Proteins. 2022, 14:121–129. DOI: 10.1007/s12602-021-09799-z.

16、             Xiao-Ying Hou,Pei Zhang,Hong-Zhi Du,Yi-Qiao Gao,Rui-Qi Sun,Si-Yuan Qin,Yuan Tian,Jing Li,Yu-Xin Zhang, Wei-Hua Chu*, Zun-Jian Zhang*, Feng-Guo Xu* Prevotella contributes to individual response of FOLFOX in colon cancer. Clinical and Translational Medicine.  2021,10.1002/ctm2.512.

17、             Shipo Li and Weihua Chu*. Influence of butyrate on the pathogenicity of Aeromonas hydrophila. Aquaculture Nutrition. 2021, 27(S1):13– 19. DOI: 10.1111/anu.13318

18、             Wang Z, Zhao Y, Jiang Y and Chu W*. Prebiotic, antioxidant, and immunomodulatory properties of acidic exopolysaccharide from marine Rhodotorula RY1801. Frontiers in Nutrition. 2021，8:710668. doi: 10.3389/fnut.2021.710668.

19、             Xianjin Qin, Wenqian Wang and Weihua Chu*. Antioxidant and reducing lipid accumulation effects of rutin in Caenorhabditis elegans. Biofactors. 2021, 47(4): 686-693, DOI: 10.1002/biof.1755.

20、             Xing Heng, Yuanhe Jiang, Weihua Chu*. Influence of fluconazole administration on gut microbiome, intestinal barrier and immune response in mice. Antimicrobial agents and chemotherapy.2021, 65(6): e02552-20, DOI: 10.1128/AAC.02552-20.

21、             Xing Heng, Wugao Liu and Weihua Chu*. Identification of choline-degrading bacteria from healthy human feces and used for screening of trimethylamine (TMA)-lyase inhibitors. Microbial Pathogenesis. 2021,152, 104658, DOI: 10.1016/j.micpath.2020.104658.

22、Jiali Tang#, Wenqian Wang#, Yuanhe Jiang and Weihua Chu*. Diazinon exposure produces histological damage, oxidative stress, immune disorders and gut microbiota dysbiosis in crucian carp (Carassius auratus gibelio). Environmental Pollution, 2021, 269: 116129. DOI: 10.1016/j.envpol.2020.116129.

23、             Jiali Tang, Wenqian Wang and Weihua Chu*. Antimicrobial and anti-quorum sensing activities of phlorotannins from seaweed (Hizikia fusiforme). Front. Cell. Infect. Microbiol. 2020, 10:586750. DOI: 10.3389/fcimb.2020.586750.

24、             Wugao Liu, Hongji Lu, Xinyu, Chu, Tianzheng Lou, Ning Zhang, Bao Zhang and Weihua Chu*.  Tea polyphenols inhibits biofilm formation, attenuates the quorum sensing-controlled virulence and enhances resistance to Klebsiella pneumoniae infection in Caenorhabditis elegans model. Microbial Pathogenesis. 2020, 147, 104266. DOI：10.1016/j.micpath.2020.104266.

25、             Xiyi Zhuang，An Zhang，Weihua Chu*. Anti-quorum sensing activity of Forsythia suspense extract against Chromobacterium violaceum by targeting CviR receptor. International Microbiology.  2020, 23: ? 215-224. DOI: 10.1007/s10123-019-00091-3.

26、             Wei Zhu，Shuxin Zhou，Weihua Chu*. Comparative proteomic analysis of sensitive and multi-drug resistant Aeromonas hydrophila isolated from diseased fish. Microbial Pathogenesis.  2020, 139, 103930.  DOI: 10.1016/j.micpath.2019.103930.

27、             Wenqian Wang，Wugao Liu, Weihua Chu*. Isolation and preliminary screening of potentially probiotic Weissella confusa strains from healthy human feces by culturomics. Microbial Pathogenesis. 2020, 147, 104356, DOI：10.1016/j.micpath.2020.104356.

28、             Huafu Wang，Xianjin Qin, Zhihong Gui, Weihua Chu* The effect of Bailemian on neurotransmitters and gut microbiota in p-chlorophenylalanine induced insomnia mice. Microbial Pathogenesis. 2020， 148，104474，DOI:10.1016/j.micpath.2020.104474.

29、             Haichao Zhao，Xueyuan Jiang，Weihua Chu*. Shifts in the gut microbiota of mice in response to dexamethasone administration. International Microbiology. 2020, 23, 565–573, DOI: 10.1007/s10123-020-00129-x.

30、             Yuanhe Jiang，Shuxin Zhou，Emmanuel Konadu Sarkodie，Weihua Chu* The effects of Bacillus cereus QSI-1 on intestinal barrier function and mucosal gene transcription in Crucian carp (Carassius auratus gibelio). Aquaculture Reports. 2020, 17, 100356, DOI: 10.1016/j.aqrep.2020.100356.

31、             Wei Zhu, Shuxin Zhou, Jihua Liu, Robert J.C. McLean and Weihua Chu*. Prebiotic, immuno-stimulating and gut microbiota-modulating effects of Lycium barbarum polysaccharide. Biomedicine & Pharmacotherapy. 2020, 121, 109591, DOI: 10.1016/j.biopha.2019.109591.

32、           Bao Zhang^#, Xiyi Zhuang^#, Liyun Guo, Robert J C McLean, and Weihua Chu*. Recombinant N-acyl homoserine lactone-Lactonase AiiA_QSI-1 attenuates Aeromonas hydrophila virulence factors, biofilm formation and reduces mortality in Crucian Carp. Marine Drugs. 2019, 17(9), 499; doi: 10.3390/md17090499.

33、           Shuxin Zhou^#, Zixun Yu^#, Weihua Chu*. Effect of quorum-quenching bacterium Bacillus sp. QSI-1 on protein profiles and extracellular enzymatic activities of Aeromonas hydrophila YJ-1. BMC Microbiology, 2019,19:135, DOI: 10.1186/s12866-019-1515-6.

34、           Emmanuel Konadu Sarkodie, Shuxin Zhou, Sarah Ama Baidoo, Weihua Chu* Influences of stress hormones on microbial infections Microbial Pathogenesis.2019, 131:270-276. 10.1016/j.micpath.2019.04.013 .

35、           Yuanhe Jiang, Shuxin Zhou, Weihua Chu*. The effects of dietary Bacillus cereus QSI-1 on skin mucus proteins profile and immune response in Crucian Carp (Carassius auratus gibelio). Fish & Shellfish Immunology. 2019, 89:319-325.

36、           Zhao, Y.; Guo, L.; Xia, Y.; Zhuang, X.; Chu, W. Isolation, identification of carotenoid-producing Rhodotorula sp. from marine environment and optimization for carotenoid production. Marine Drugs. 2019, 17(3), 161. doi:10.3390/md17030161。

37、           Shuxin Zhou, An Zhang and Weihua Chu. Phillyrin is an effective inhibitor of quorum sensing with potential as an anti-Pseudomonas aeruginosa infection therapy. J. Vet. Med. Sci. 2019, 81(3): 473–479, doi: 10.1292/jvms.18-0523。

38、           Hong Wang^#, Weihua Chu^#, Chao Ye, Bruno Gaeta, Huimin Tao, Min Wang*, Zheng Qiu*. Chlorogenic acid attenuates virulence factors and pathogenicity of Pseudomonas aeruginosa by regulating quorum sensing. Applied Microbiology and Biotechnology. 2019, 103(2): 903–915. doi.org/10.1007/s00253-018-9482-7.