个人简介

侯筱宇，二级教授，博士生导师。江苏省生物化学与分子生物学会监事，江苏省神经科学学会常务理事。1992年毕业于中国药科大学药物分析专业，获学士学位；1998年获徐州医科大学生物化学专业硕士学位；2003年获中国科学院上海药物研究所药理学专业博士学位；2009-2010年国际著名神经科学家梅林教授实验室（Medical College of Georgia at Augusta University, USA）博士后/高级访问学者。主要研究代谢应激和炎症状态等引起神经精神障碍的生物学机制，探寻并确证脑保护分子靶点和治疗药物。先后主持国家自然科学基金面上项目6项，部省级重大研究计划项目等8项；指导团队青年教师获国家自然科学基金项目8项。以通讯作者在PNAS、Cell Death & Differentiation、Cell Death & Diseases、Stroke和Neuropsychopharmacology等国际知名学术期刊发表研究论文；获江苏省科学技术奖二等奖1项、三等奖2项，中华医学科技奖二等奖1项；申请国家发明专利8项，已授权3项。主编生物化学与分子生物学等教材3部，其中国家级和省级规划教材1部。入选教育部新世纪优秀人才、江苏省有突出贡献中青年专家、江苏省“333工程”中青年科技领军人才（第二层次）、江苏省“六大人才高峰”和江苏省“青蓝工程”科技创新团队带头人等。

目前主要研究方向

1、基于细胞稳态的脑保护机制和靶点药物研究

2、炎症调控与脑保护分子靶点研究

3、神经保护天然药物活性成分的筛选及其药理机制研究

以通讯作者发表的主要科研成果

Shi D, Bai Y, Long R, Xia J, Xu W, Qin D, Yang X, Ding M*, Hou XY*. Neuronal LAMP2A-mediated reduction of adenylyl cyclases induces acute neurodegenerative responses and neuroinflammation after ischemic stroke. Cell Death Differ. 2024 Sep 28. doi: 10.1038/s41418-024-01389-0.
Xia J, Zhang T, Sun Y, Huang Z, Shi D, Qin D, Yang X, Liu H, Yao G, Wei L, Chang X, Gao J*, Guo Y*, Hou XY*. Suppression of neuronal CDK9/p53/VDAC signaling provides bioenergetic support and improves post-stroke neuropsychiatric outcomes. Cell Mol Life Sci, 2024, 81(1):384.
Ruan Q, Geng Y, Zhao M, Zhang H, Cheng X, Zhao T, Yue X, Jiang X, Jiang X, Hou XY*, Zhu LL*. Prolyl hydroxylase inhibitor FG-4592 alleviates neuroinflammation via HIF-1/BNIP3 signaling in microglia. Biomed Pharmacother, 2024, 173:116342.
Wu Q, Wu JH, Ye ZY, She W, Peng WJ, Zhang HX, Qi C, Tian T, Hou XY*, Gao J*. Exosomes from hypoxia-treated mesenchymal stem cells: promoting neuroprotection in ischemic stroke through miR-214-3p/PTEN mechanism. Mol Neurobiol. 2024, 61(10):7611-7626.
Xu Y, Wang ML, Tao H, Geng C, Guo F, Hu B, Wang R, Hou XY*. ErbB4 in parvalbumin-positive interneurons mediates proactive interference in olfactory associative reversal learning. Neuropsychopharmacology, 2022, 47(7):1292-1303.
Meng L, Du CP, Lu CY, Zhang K, Li L, Yan JZ*, Hou XY*. Neuronal activity-induced SUMOylation of Akt1 by PIAS3 is required for long-term potentiation of synaptic transmission. FASEB J, 2021, 35(8):e21769.
Hu B, Geng C, Guo F, Liu Y, Zong YC, Hou XY*. GABAA receptor agonist muscimol rescues inhibitory microcircuit defects in the olfactory bulb and improves olfactory function in APP/PS1 transgenic mice. Neurobiol Aging, 2021, 108:47-57.
Du CP, Wang M, Geng C, Hu B, Meng L, Xu Y, Cheng B, Wang N, Zhu QJ, Hou XY*. Activity-induced SUMOylation of neuronal nitric oxide synthase is associated with plasticity of synaptic transmission and extracellular signal-regulated kinase 1/2 signaling. Antioxid Redox Signal, 2020, 32(1):18-34.
Yao GY, Zhu Q, Xia J, Chen FJ, Huang M, Liu J, Zhou TT, Wei JF, Cui GY, Zheng KY, Hou XY*. Ischemic postconditioning confers cerebroprotection by stabilizing VDACs after brain ischemia. Cell Death Dis, 2018, 9(10):1033.
Hu B, Geng C, Hou XY*. Oligomeric amyloid-beta peptide disrupts olfactory information output by impairment of local inhibitory circuits in rat olfactory bulb. Neurobiol Aging, 2017, 51:113-121.
Zhao C, Du CP, Peng Y, Xu Z, Sun CC, Liu Y, Hou XY*. The upregulation of NR2A-containing N-methyl-D-aspartate receptor function by tyrosine phosphorylation of postsynaptic density 95 via facilitating Src/proline-rich tyrosine kinase 2 activation. Mol Neurobiol, 2015, 51(2):500-511.
Zhu QJ, Kong FS, Xu H, Wang Y, Du CP, Sun CC, Liu Y, Li T, Hou XY*. Tyrosine phosphorylation of GluK2 up-regulates kainate receptor-mediated responses and downstream signaling after brain ischemia. Proc Natl Acad Sci U S A, 2014, 111(38):13990-13995.
Liu J, Xu Q, Wang H, Wang R, Hou XY*. Neuroprotection of ischemic postconditioning by downregulating the postsynaptic signaling mediated by kainate receptors. Stroke, 2013, 44(7):2031-2035.
Du CP, Gao J, Tai JM, Liu Y, Qi J, Wang W, Hou XY*. Increased tyrosine phosphorylation of PSD-95 by Src family kinases after brain ischaemia. Biochem J, 2009, 417(1):277-285.

实验室及通讯地址

江苏省南京市鼓楼区童家巷24号中国药科大学玄武校区科研楼（210009）

个人经历

科研项目

科研专利

发表论文

获奖成果

教材专著