张洁琳，博士，化学生物学研究室，特聘副研究员，硕士研究生导师。2010 年和2013年于中国药科大学获得学士与硕士学位，2014 年至2019年于荷兰格罗宁根大学药学研究院进行博士研究学习，导师 Gerrit J. Poelarends教授，主要方向为基于碳-氮键裂解酶的新型生物催化剂的开发、生物催化不对称合成生物活性非天然氨基酸。2019 年进入中国药科大学化学生物研究室工作。迄今在Nature Catalysis、Angewandte Chemie International Edition、ACS Catalysis、Advanced Synthesis and Catalysis等国际学术期刊发表研究论文11 篇。主持国家自然科学基金青年项目和江苏省自然科学基金青年基金各1项，江苏省“双创计划”双创博士入选者。

代表论文：

(1)  Jielin Zhang; Eleonora Grandi; Haigen Fu; Thangavelu Saravanan; Laura Bothof; Pieter G. Tepper; Andy-Mark W. H. Thunnissen; Gerrit J. Poelarends*; Engineered C–N Lyase: Enantioselective Synthesis of Chiral Synthons for Artificial Dipeptide Sweeteners, Angewandte Chemie International Edition, 2020, 59(1): 429-435.

(2)   Haigen Fu#; Jielin Zhang#; Mohammad Saifuddin#; Gea Cruiming; Pieter G. Tepper; Gerrit J. Poelarends*; Chemoenzymatic Asymmetric Synthesis of the Metallo-β-Lactamase Inhibitor Aspergillomarasmine A and Related Aminocarboxylic Acids, Nature Catalysis, 2018, 1: 186-191.

(3)   Jielin Zhang; Haigen Fu; Pieter G. Tepper; Gerrit J. Poelarends*; Biocatalytic Enantioselective Hydroaminations for Production of N-Cycloalkyl-Substituted L-Aspartic Acids Using Two C-N Lyase, Advanced Synthesis and Catalysis, 2019, 361(11): 2433-2437.

(4)   Jielin Zhang; Shanshan Tao; Baojie Zhang; Xuri Wu; Yijun Chen*; Microparticle-Based Strategy for Controlled Release of Substrate for the Biocatalytic Preparation of L?Homophenylalanine, ACS Catalysis, 2014, 4(5): 1584-1587.

(5)   Jielin Zhang; Tianyi Zhu; Xuri Wu; Yijun Chen*; Enhancement of Biocatalytic Efficiency by Increasing Substrate Loading: Enzymatic Preparation of L-Homophenylalanine, Applied Microbiology and Biotechnology, 2013, 97(19): 8487-8494.

(6)  Jielin Zhang; Mohammad Z. Abidin; Thangavelu Saravanan; Gerrit J. Poelarends*; Recent Applications of Carbon-Nitrogen Lyases in Asymmetric Synthesis of Noncanonical Amino Acids and Heterocyclic Compounds, ChemBioChem, 2020, 21(19): 2733-2742.

(7)   Harshwardhan Poddar#; Jandré de Villiers#; Jielin Zhang; Vinod Puthan Veetil; Hans Raj; Andy-Mark W. H. Thunnissen; Gerrit J. Poelarends*; Structural Basis for the Catalytic Mechanism of Ethylenediamine-N,N’-Disuccinic Acid Lyase, a Carbon-Nitrogen Bond-Forming Enzyme with Broad Substrate Scope, Biochemistry, 2018, 57(26): 3752-3763.

(8)   Haigen Fu; Jielin Zhang; Pieter G. Tepper; Lennart Bunch; Anders A. Jensen; Gerrit J. Poelarends*, Chemoenzymatic Synthesis and Pharmacological Characterization of Functionalized Aspartate Analogues as Novel Excitatory Amino Acid Transporter Inhibitors, Journal of Medicinal Chemistry, 2018, 61(17): 7741-7753. 

(9)   Mohammad Z. Abidin; Thangavelu Saravanan; Jielin Zhang; Pieter G. Tepper; Erick Strauss; Gerrit J. Poelarends*; Modular Enzymatic Cascade Synthesis of Vitamin B5 and its Derivatives,  Chemistry-A European Journal, 2018, 24(66): 17434-17438.