徐莉莉，药物化学博士，副研究员，硕士生导师。2017年获得中国药科大学制药工程学专业（硕博连读）博士学位，同年在中国药科大学药物分析教研室从事师资博士后研究工作，2020年7月博士后出站留在药物分析教研室从事讲师，2021年7月获聘副研究员职称。

       目前主持国家自然科学基金面上项目一项，国家自然科学基金青年基金项目一项，江苏省自然科学基金青年基金一项，中国博士后基金面上项目一项，中央高校基本科研业务费重点项目一项等。主要研究方向为运用药物分析学、蛋白质组学、化学生物学、药物化学、计算机辅助药物设计等多学科交叉手段，开展原创药物研发、靶标发现与确证、新分析方法开发及禁毒相关研究等。

      在高水平期刊如Acta Pharmaceutica Sinica B、Analytical Chemistry、Journal of Medicinal Chemistry、Nanoscale、Journal of Autoimmunity、Free Radical Biology and Medicine、European Journal of Medicinal Chemistry等发表论文40余篇，发明专利十余项，曾获岛津青年学者奖。

联系方式

Email：xulili@cpu.edu.cn

代表性论文：

[1]    Dai, Z.^#; An, L. Y. ^#; Chen, X. Y. ^#; et al; You, Q. D.^*; Di, B.^*; Xu, L. L.^* Target fishing reveals a novel mechanism of 1,2,4-oxadiazole derivatives targeting to Rpn6, a subunit of 26S Proteasome, Journal of Medicinal Chemistry, 2022, 65, 5029?5043. (SCI, IF = 8.039)

[2]    Wang Y. H. ^#; Zhou M. Z. ^#; Ye Ta; Wang P. P.; Lu R.; Wang Y. L.; Liu C. X.; Xiao W.; Li J. Y.; Meng Z. B.; Xu L. L. ^*; Hu Q. H. ^*; and Jiang C.^* Discovery of a Series of 5-Amide-1H-pyrazole-3-carboxyl Derivatives as Potent P2Y₁₄R Antagonists with Anti-Inflammatory Characters. Journal of Medicinal Chemistry, 2022, 65, 23, 15967–15990. (SCI, IF = 8.039)

[3]    Dai, Z.; Chen, X. Y.; An, L. Y.; Li, C. C.; Zhao, N.; Yang, F.; You, S. T.; Hou, C. Z.; Li, K.; Jiang, C.^*; You, Q. D.^*; Di, B.^*; Xu, L. L.^*, Development of Novel Tetrahydroquinoline Inhibitors of NLRP3 Inflammasome for Potential Treatment of DSS-Induced Mouse, Journal of Medicinal Chemistry, 2021, 64, 871-889. (SCI, IF = 8.039)

[4]    Li, C. C.; Zhao, N.; An, L. Y.; Dai, Z.; Chen, X. Y.; Yang, F.; You, Q. D.; Di, B.^*; Hu, C.^*; Xu, L. L.^*, Apoptosis-inducing activity of synthetic hydrocarbon-stapled peptides in H358 cancer cells expressing KRAS^G12C, Acta Pharmaceutica Sinica B, 2021, 11(9), 2670e2684. (SCI, IF = 14.907)

[5]    Zhao, N.; Di, B.^*; Xu, L. L.^*, The NLRP3 inflammasome and COVID-19: Activation, pathogenesis and therapeutic strategies. Cytokine and Growth Factor Reviews, 2021, 61, 2–15. (SCI, IF = 17.660)

[6]    Zhao, N.; Li, C. C.; Di, B.^*; Xu, L. L.^*, Recent advances in the NEK7-licensed NLRP3 inflammasome activation: Mechanisms, role in diseases and related inhibitors, Journal of Autoimmunity, 2020, 113, 102515. (SCI, IF = 14.511)

[7]    Cheng, S.; Shen, H.; Zhao, S.; Zhang, Y.; Xu, H.; Wang, L.; Di, B.^*; Xu, L. L.^*; Hu, C.^*, Orally administered mesoporous silica capped with the cucurbit[8]uril complex to combat colitis and improve intestinal homeostasis by targeting the gut microbiota, Nanoscale, 2020, 12(28), 15348-15363. (SCI, IF = 8.307)

[8]    Xu, L. L.; Li, C. C.; An, L. Y.; Dai, Z.; Chen, X. Y.; You, Q. D.^*; Hu, C.^*; Di, B.^*, Selective apoptosis-inducing activity of synthetic hydrocarbon-stapled SOS1 helix with D-amino acids in H358 cancer cells expressing KRAS^G12C, European Journal of Medicinal Chemistry, 2020, 185, 111844. (SCI, IF = 7.088)

[9]    Jia, J.; Wen, H.; Zhao, S.; Wang, L.; Qiao, H.; Shen, H.; Yu, Z.; Di, B.^*; Xu, L. L.^*; Hu, C.^*, Displacement Induced Off-On Fluorescent Biosensor Targeting IDO1 Activity in Live Cells, Analytical Chemistry, 2019, 91 (23), 14943-14950. (SCI, IF = 8.008)

[10] Xu, L. L.; Wu, Y. F.; Yan, F.; Li, C. C.; Dai, Z.; You, Q. D.^*; Jiang, Z. Y.^*; Di, B.^*, 5-(3,4-Difluorophenyl)-3-(6-methylpyridin-3-yl)-1,2,4-oxadiazole (DDO-7263), a novel Nrf2 activator targeting brain tissue, protects against MPTP induced subacute Parkinson's disease in mice by inhibiting the NLRP3 inflammasome and protects PC12 cells against oxidative stress, Free Radical Biology and Medicine, 2019,134, 288-303. (SCI, IF = 8.101)