张悦，博士，副研究员，硕士生导师。2020年毕业于中国药科大学药物代谢动力学重点实验室。博士毕业后留校工作，主要从事肠-脑神经环路介导的药理与病理机制研究、抗抑郁新药作用机制与转化研究等工作。主持国家自然科学基金青年项目1项，同时作为核心骨干参与国家新药创制重大专项、江苏省重大专项、江苏省前沿引领技术基础研究专项等多个国家及省部级项目。以第一作者或通讯作者在Biological Psychiatry、Acta Pharmaceutica Sinica B、Journal of Proteome Research、Journal of Pharmaceutical and Biomedical Analysis等期刊发表SCI论文十余篇，并担任J Immunol Res、JPBA等国际期刊审稿人。研究成果获2019年度南京市十大原创科技成果。

主要研究方向

1、 肠-脑神经环路介导的药理与病理机制研究

2、 抗抑郁新药作用机制与转化研究

代表性论著

1、Zhang Y, Gao JW, Li N, Xu P, Qu SM, Cheng JQ, Wang MR, Li XR, Song YH, Xiao F, Yang XY, Liu JH, Hong H, Mu RH, Li XT, Wang YM, Xu H, Xie Y, Gao TM, Wang GJ*, Aa JY*. Targeting cAMP in D1-MSNs in the nucleus accumbens, a new rapid antidepressant strategy, Acta Pharmaceutica Sinica B, 2024, 14(2):667-681.（IF=14.9）

2、Zhang Y, Lu W, Wang Z, Zhang R, Xie Y, Guo S, Jiao L, Hong Y, Di Z, Wang G*, Aa J*. Reduced neuronal cAMP in the nucleus accumbens damages blood-brain barrier integrity and promotes stress vulnerability, Biological Psychiatry, 2020 Mar 15, 87(6):526-537. (IF=12.1)

3、Ge C#, Huang X#, Zhang S#, Yuan M, Tan Z, Xu C, Jie Q, Zhang J, Zou J, Zhu Y*, Feng D*, Zhang Y*, Aa J. In vitro co-culture systems of hepatic and intestinal cells for cellular pharmacokinetic and pharmacodynamic studies of capecitabine against colorectal cancer, Cancer Cell Int, 2023 Jan 31, 23(1):14. (IF=6.4)

4、Lu Z#, Li S#, Aa N, Zhang Y, Zhang R, Xu C, Zhang S, Kong X, Wang G, Aa J*, Zhang Y*. Quantitative analysis of 20 purine and pyrimidine metabolites by HILIC-MS/MS in the serum and hippocampus of depressed mice, J Pharm Biomed Anal, 2022 Sep 20, 219:114886. (IF=3.6)

5、Zhang Y, Geng J, Hong Y, Jiao L, Li S, Sun R, Xie Y, Yan C, Aa J*, Wang G. Orally Administered Crocin Protects Against Cerebral Ischemia/Reperfusion Injury Through the Metabolic Transformation of Crocetin by Gut Microbiota, Frontiers in Pharmacology, 2019 Apr 30, 10:440. (IF=3.8)

6、Zhang Y, Fei F, Zhen L, Zhu X, Wang J, Li S, Geng J, Sun R, Yu X, Chen T, Feng S, Wang P, Yang N, Zhu Y, Huang J, Zhao Y, Aa J*, Wang G. Sensitive analysis and simultaneous assessment of pharmacokinetic properties of crocin and crocetin after oral administration in rats, Journal of Chromatography B, 2017 Feb 15, 1044-1045:1-7. (IF=2.8)

7、Jiao Z, Lu Z, Peng Y, Xu C, Lou Y, Wang G, Aa J*, Zhang Y*. A quantitative metabolomics assay targeting 14 intracellular metabolites associated with the methionine transsulfuration pathway using LC-MS/MS in breast cancer cells, Journal of Chromatography B, 2022 Aug 1;1205:123314. (IF=3.3)

8、Geng J, Zhang Y, Li S, Li S, Wang J, Wang H, Aa J*, Wang G*. Metabolomic Profiling Reveals That Reprogramming of Cerebral Glucose Metabolism Is Involved in Ischemic Preconditioning-Induced Neuroprotection in a Rodent Model of Ischemic Stroke, Journal of Proteome Research, 2019 Jan 4, 18(1):57-68. (IF=3.9)