中国药科大学药物科学研究院药物代谢动力学重点实验室研究员，博士生导师。曾经在瑞典Umea大学、英国伦敦大学访学，专注于药代动力学、代谢组学研究。在创新药物成药性研究、中药药效物质基础与作用机理研究、血脑屏障损伤、抗抑郁研究等方面取得进展，主持国家级、省部级课题7项。其中“基于药动-药效结合的组分中药与创新中药研发关键技术”获 “十三五”国家重大新药创新专项资助，在包括Molecular Cancer, Biological Psychiatry, APSB,Analytical Chemistry, Pharmacological Research, Acta Pharmacological sinica, Drug Metabolism and Disposition, Metabolomics等高水平专业杂志发表论文75篇，申请发明专利9项，获得授权3项。

参与组织和编写新版中国大百科全书《现代医学》分支《药代动力学》、《代谢组学》、人民卫生出版社研究生教材《药代动力学理论与实践》等。为《药学学报》、《中国药科大学学报》、《中国临床药理学与治疗学杂志》编委、多个SCI期刊杂志审稿人、江苏省“333高层次人才培养工程”第二层次培养对象。参加研究的一类新药盐酸关附甲素、银杏二萜内酯葡胺注射液获得新药证书，研究成果“银杏二萜内酯强效应组合物的发明及制备关键技术与应用”获国家级技术发明二等奖、“临床前药物代谢动力学关键技术与研究体系”获国家科技进步二等奖、“中药药代动力学关键技术体系的创新及应用”与“细胞药代动力学新理论技术体系的创建及其在新药研发和临床用药中的应用”获江苏省科技进步一等奖。

近期发表主要论文   

1.  Mengjie Yu, Cheng Liu，Minmin Cao, Guangji Wang*, Jiye Aa*, Wei Zhu*（2025）,Purine metabolism: a pan-cancer metabolic dysregulation across circulation and tissues. Molecular Cancer, Available online at:  https://molecular-cancer.biomedcentral.com/articles/10.1186/s12943-025-02482-9（学科顶尖）

2.         Zhang, Y., Gao, J., Li, N., Xu, P., Qu, S., Cheng, J., Wang, M., Li, X., Song, Y., Xiao, F., Yang, X., Liu, J., Hong, H., Mu, R., Li, X., Wang, Y., Xu, H., Xie, Y., Gao, T., Wang, G.* & Aa, J. *(2024) Targeting cAMP in D1-MSNs in the nucleus accumbens, a new rapid antidepressant strategy, Acta Pharm Sin B. 14, 667-681.（学科顶尖）

3.         Tan, Z., Ge, C., Feng, D., Xu, C., Cao, B., Xie, Y., Zhou, H.*, Wang, G. & Aa, J.* (2021) The Interleukin-6/Signal Transducer and Activator of Transcription-3/Cystathionine gamma-Lyase Axis Deciphers the Transformation Between the Sensitive and Resistant Phenotypes of Breast Cancer Cells, Drug Metab Dispos. 49, 985-994.（学科一流）

4.         Li, S. J., Cao, B., Lu, Z. Y., Sun, R. B., Guo, S. H., Xie, Y., Aa, J. Y. *& Wang, G. J. (2021) Cystine supplementation rebalances the redox homeostasis of microenvironment in non-small cell lung cancer cells and reverses their resistance to docetaxel, Acta Pharmacol Sin. 42, 2132-2143.（学科一流）

5.         Sun, R., Kong, B., Yang, N., Cao, B., Feng, D., Yu, X., Ge, C., Feng, S., Fei, F., Huang, J., Lu, Z., Xie, Y., Yang, C. S., Guo, G. L., Wang, G.* & Aa, J.* (2021) The Hypoglycemic Effect of Berberine and Berberrubine Involves Modulation of Intestinal Farnesoid X Receptor Signaling Pathway and Inhibition of Hepatic Gluconeogenesis, Drug Metab Dispos. 49, 276-286.（学科一流）

6.         Zhang, Y., Lu, W., Wang, Z., Zhang, R., Xie, Y., Guo, S., Jiao, L., Hong, Y., Di, Z., Wang, G.* & Aa, J.* (2020) Reduced Neuronal cAMP in the Nucleus Accumbens Damages Blood-Brain Barrier Integrity and Promotes Stress Vulnerability, Biological psychiatry. 87, 526-537.（学科顶尖）

7.         Aa, L. X., Fei, F., Qi, Q., Sun, R. B., Gu, S. H., Di, Z. Z., Aa, J. Y.*, Wang, G. J. & Liu, C. X.* (2020) Rebalancing of the gut flora and microbial metabolism is responsible for the anti-arthritis effect of kaempferol, Acta Pharmacol Sin. 41, 73-81. （学科一流）

8.         Fei, F., Aa, L. X., Qi, Q., Sun, R. B., Yan, C. X., Aa, J. Y*. & Wang, G. J. (2019) Paeoniflorin inhibits Th1 and Th17 cells in gut-associated lymphoid tissues to produce anti-arthritis activities, Inflammopharmacology. 27, 1193-1203. （学科重要）

9.         Yang, N., Sun, R., Liao, X., Aa, J.* & Wang, G. (2017) UDP-glucuronosyltransferases (UGTs) and their related metabolic cross-talk with internal homeostasis: A systematic review of UGT isoforms for precision medicine, Pharmacol Res. 121, 169-183.（学科一流）

10.     Cao, B., Li, M., Zha, W., Zhao, Q., Gu, R., Liu, L., Shi, J., Zhou, J., Zhou, F., Wu, X., Wu, Z., Wang, G. & Aa, J.* (2013) Metabolomic approach to evaluating adriamycin pharmacodynamics and resistance in breast cancer cells, Metabolomics. 9, 960-973.（专业权威）